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ProteomicsApolipoprotein A1 forms 5/5 and 5/4 antiparallel dimers in human high-density lipoprotein
We performed zero-order chemical cross-linking mass spectrometry experiments on reconstituted discoidal HDL and human HDL to determine the APOA1 orientations in these particles.
ORGANISM(S): Homo sapiens (Human) 
2019-04-09 | PXD009927 | Pride
Molecular modeling Apoa1 Chemical cross-linking High density lipoprotein Tandem mass spectrometric analysis 
GenomicsSingle cell gene expression profile of bronchoalveolar lavage fluid (BALF) cells from Apoa1-/- and Apoa1+/+ mice challenged with LPS and house dust mite
Single cell gene expression profile of bronchoalveolar lavage fluid (BALF) cells from Apoa1-/- and Apoa1+/+ mice challenged with LPS and house dust mite
PRJNA980690 | ENA
GenomicsApoa1, a safe harbor locus for therapeutic genome editing in the liver
Apoa1, a safe harbor locus for therapeutic genome editing in the liver
PRJNA641134 | ENA
GenomicsBulk RNA-seq of microglia from Apoa1 KO mice injected with ApoA-I protein intravenously
Bulk RNA-seq of microglia from Apoa1 KO mice injected with ApoA-I protein intravenously
PRJNA1101003 | ENA
GenomicsN39 APOA1-tdTomato drug screen
N39 APOA1-tdTomato drug screen
PRJNA1142560 | ENA
TranscriptomicsSingle cell gene expression profile of bronchoalveolar lavage fluid (BALF) cells from Apoa1-/- and Apoa1+/+ mice challenged with LPS and house dust mite
Neutrophils play important roles in inflammatory airway diseases. Here, we assessed whether apolipoprotein A-I (apoA-I) modifies neutrophil heterogeneity as part of the mechanism by which it attenuates acute airway inflammation. Neutrophilic airway inflammation was induced by daily intranasal admini...
ORGANISM(S): Mus musculus 
2024-07-29 | GSE234287 | GEO
TranscriptomicsTranscription profiling of mouse knockouts vs wild type apoE knockout,apoA1 knockout, apoA1 transgene, apoB knockout, mice were fed normal vs artherogenic diets
Collect tissues from control C57kBL/6 and the following genetically engineered mice-apoE knockout,apoA1 knockout, apoA1 transgene, apoB knockout, LDLR knockout.Both male and female mice fed chow or atherogenic diet will be used. Animals from each group were pooled into 2 pools, one containing 4 mice...
ORGANISM(S): Mus musculus 
2010-10-10 | E-TIGR-110 | biostudies-arrayexpress
GenomicsApoa1, a safe harbor locus for therapeutic genome editing in the liver
Clinical application of somatic genome editing requires therapeutics that are generalizable to a broad range of patients. Targeted insertion of promoterless transgenes can ensure that edits are permanent, broadly applicable, while minimizing risks of off-target integration. In the liver, the Albumin...
ORGANISM(S): Mus musculus 
2021-06-01 | GSE152993 | GEO
UnknownSIDT2 Associates with Apolipoprotein A1 (ApoA1) and Facilitates ApoA1 Secretion in Hepatocytes.
Not available
S-EPMC10571540 | biostudies-literature
TranscriptomicsRNA-seq analysis of human hepatocyte Huh7 cells transfected with CRISPR/(d)Cas9 plasmids for transcriptional activation of APOA1 and PON1
The aim of the present study was to obtain and characterize an in vitro model for endogenous APOA1 and PON1 long-time up-regulation in hepatocytes that can be further used to decipher the mechanism of their protective action. Cultured human hepatocytes (HuH-7 cell line) were transfected with CRISPR/...
ORGANISM(S): Homo sapiens 
2026-07-03 | E-MTAB-17152 | biostudies-arrayexpress
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