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TranscriptomicsExpression data from articular and growth plate cartilage
The aim of the current study was to identify molecular markers for articular cartilage that can be used for the quality control of tissue engineered cartilage. Therefore a genom-wide expression analysis was performed using RNA isolated from articular and growth plate cartilage, both extracted from t...
ORGANISM(S): Sus scrofa 
2011-07-28 | E-GEOD-23492 | biostudies-arrayexpress
TranscriptomicsComparison of steady state mRNA levels between equine articular cartilage and ten other equine tissues
A tissue survey of gene expression was conducted using microarray-based transcriptional profiling to compare equine articular cartilage to 10 other normal adult horse tissues. The ten comparative tissues were bladder, cerebellum, kidney, liver, lung, lymph node, muscle, placental villous, spleen, a...
ORGANISM(S): Equus caballus 
2011-01-27 | E-GEOD-23862 | biostudies-arrayexpress
TranscriptomicsSpatial Regulation of Gene Expression in Articular Cartilage Assessed by Laser Captured Microdissection and Microarray
We used laser capture microdissection to isolate different zones of the articular cartilage from proximal tibiae of 1-week old mice, and used microarray to analyze global gene expression. Bioinformatic analysis corroborated previously known signaling pathways, such as Wnt and Bmp signaling, and impl...
ORGANISM(S): Mus musculus 
2014-10-20 | E-GEOD-51994 | biostudies-arrayexpress
TranscriptomicsPost-transcriptional gene regulation following exposure of human articular chondrocytes to hyperosmotic conditions
Exposing freshly isolated human articular chondrocytes to hyperosmotic conditions (550 mOsm vs 380mOsm controls) for 5 hours and then performing transcriptome analysis using Illumina Ref8 arrays.
ORGANISM(S): Homo sapiens 
2011-03-02 | E-MEXP-3129 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of articular cartilage reveals functional pathways and networks of candidate genes for osteochondrosis in pigs
Osteochondrosis disorder is characterized by a failure of endochondral ossification of the articular-epiphyseal cartilage and the physeal growth cartilage. The number and identity of relevant genes are unknown. Simultaneously, 24,123 probe-sets were screened, of which 12,292 had present in at least ...
ORGANISM(S): Sus scrofa 
2013-10-21 | E-GEOD-44991 | biostudies-arrayexpress
TranscriptomicsGenome wide-DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients (methylation)
The aim of this study is to identify, for the first time, the genome-wide DNA methylation profiles of human articular chondrocytes from OA and healtly cartilage samples. Genome wide DNA methylation profiling of normal and osteoarthritic samples. The Illumina Infinium 27k Human DNA methylation Beadch...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-43269 | biostudies-arrayexpress
TranscriptomicsGenome wide-DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients (gene expression)
The aim of this study is to identify, for the first time, the genome-wide DNA methylation profiles of human articular chondrocytes from OA and healtly cartilage samples. A subsequent validation of methylation profiles were performed in an idependent cohort of OA samples with Affymetrix Hugene 1.1 st...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-43191 | biostudies-arrayexpress
ProteomicsUbiquitomics and proteomics analysis of porcine articular cartilage post mechanical injury
We describe ubiquitomics and proteomics analysis of porcine articular cartilage post mechanical injury. Analysis showed ubiquitin peptides differentially enriched post injury compared to non injured controls.
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-12-19 | PXD030817 | Pride
Injury Cartilage Ubiquitomics 
TranscriptomicsGenes regulated by TGF-beta in bovine articular chondrocytes
Bovine articular chondrocytes were grown in micromass culture and were either untreated or treated with 5 ng TGF-b1/ml for 8 hours to identify genes regulated by TGF-b. Six total samples were analyzed. Three biological replicates of untreated bovine articular chondrocytes grown in micromass culture ...
ORGANISM(S): Bos taurus 
2011-09-30 | E-GEOD-29233 | biostudies-arrayexpress
ProteomicsArticular cartilage proteome differentiates by zones during osteoarthritis
Articular cartilage is deprived of blood vessels and nerves, and the only cells residing in this tissue are chondrocytes. The molecular properties of the articular cartilage and the architecture of the extracellular matrix demonstrate a complex structure that differentiates on the depth of tissue. O...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD029116 | Pride
Osteoarthritis Zonal changes and ageing 
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