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MetabolomicsPhotoperiod-mediated transcriptional and metabolic reprogramming confers salt stress tolerance via the ascorbate-glutathione cycle and phenylpropanoid pathway in Ginkgo biloba
Ginkgo biloba, one of the oldest extant relict tree species, is highly valued for its medicinal properties. However, soil salinization has emerged as a severe global ecological challenge, substantially restricting plant growth, development, and geographical distribution. While light signaling, parti...
2026-07-22 | MTBLS15130 | MetaboLights
TranscriptomicsImpact of oxidative stress on ascorbate biosynthesis in Chlamydomonas via regulation of the VTC2 gene encoding a GDP-l-galactose phosphorylase
The l-galactose (Smirnoff-Wheeler) pathway represents the major route to l-ascorbic acid (vitamin C) biosynthesis in plants. Arabidopsis thaliana VTC2 and its paralogue VTC5 function as GDP-l-galactose phosphorylases converting GDP-l-galactose to l-galactose-1-P, thus catalyzing the first committed ...
ORGANISM(S): Chlamydomonas reinhardtii 
2012-05-02 | E-GEOD-34826 | biostudies-arrayexpress
TranscriptomicsAscorbate, ascorbate oxidase and the acclimation of photosynthesis to high light
Ascorbate (vitamin C) is an important antioxidant in leaves with multiple functions in photosynthesis and its levels are tightly regulated by light quality. The majority of work to date has focussed on regulation of ascorbate levels via biosynthesis. However, the pathway of ascorbate degradation, ...
ORGANISM(S): Nicotiana tabacum 
2017-03-01 | E-MTAB-4816 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Caco-2 cell differentiation by ascorbate-stabilized quercetin
The aim was to investigate mechanisms contributing to quercetin’s previously described effects on cell-proliferation and -differentiation, which contradicted its proposed anti-carcinogenic potency. In a 10-day experiment, 40 µM quercetin stabilized by 1mM ascorbate reduced Caco-2 differentiation ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7259 | biostudies-arrayexpress
ModelsValero2016 - Ascorbate-Glutathione cycle in chloroplasts under light/dark conditions
Valero2016 - Ascorbate-Glutathione cycle in chloroplasts under light/dark conditions This model is described in the article: Modeling the ascorbate-glutathione cycle in chloroplasts under light/dark conditions. Valero E, Macià H, De la Fuente IM, Hernández JA, González-Sánchez M...
2024-09-02 | BIOMD0000000589 | BioModels
GenomicsArabidopsis lines with modified ascorbate concentrations reveal a link between ascorbate and auxin biosynthesis
Arabidopsis lines with modified ascorbate concentrations reveal a link between ascorbate and auxin biosynthesis
PRJNA1261701 | ENA
TranscriptomicsTranscription profiling of Arabidopsis wild-type, thylakoidal ascorbate peroxidase overexpressor (over tAPX, line 14/2), flu mutant and flu plants overexpressing thylakoidal ascorbate peroxidase
We used the flu mutant of Arabidopsis and a transgenic line that overexpresses the thylakoid-bound ascorbate peroxidase (tAPX) to address the interactions between different reactive oxygen species (ROS) signaling pathways. The conditional flu mutant of Arabidopsis accumulates excess protochlorophyll...
ORGANISM(S): Arabidopsis thaliana 
2008-04-05 | E-GEOD-10812 | biostudies-arrayexpress
TranscriptomicsGene expression between dry and imbibed seeds in vitamin C defective (vtc) mutants and wild-type Arabidopsis thaliana
In the dry state, orthodox seeds have little antioxidant capacity, relying on reduced glutathione and tocochromanols for antioxidant defences rather than ascorbate or ascorbate peroxidase (APX). Ascorbate is synthesised de novo within a few hours of imbibition resulting in rapid increases in the asc...
ORGANISM(S): Arabidopsis thaliana 
2017-07-03 | E-MTAB-5103 | biostudies-arrayexpress
GenomicsAscorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells
Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells
PRJNA495826 | ENA
TranscriptomicsArabidopsis lines with modified ascorbate concentrations reveal a link between ascorbate and auxin biosynthesis
Ascorbate is the most abundant water-soluble antioxidant in plants and an essential molecule for normal plant development. Although present in all green plants, ascorbate concentrations vary among plant species and tissues. While ascorbate accumulation is a trait of nutritional, and therefore, agron...
ORGANISM(S): Arabidopsis thaliana 
2025-05-17 | GSE296827 | GEO
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