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TranscriptomicsDifferential gene expression profiles between SKOV3.ip1-S116A cells (Ser116 of PEA-15 substituted with alanine) and SKOV3.ip1-S116D cells (Ser116 of PEA-15 substituted with aspartic acid).
To dissect the molecular mechanisms of PEA-15-mediated paclitaxel sensitization in ovarian cancer cells, we performed cDNA microarray analysis using SKOV3.ip1-S116A cells (Ser116 of PEA-15 substituted with alanine) and SKOV3.ip1-S116D cells (Ser116 of PEA-15 substituted with aspartic acid). cDNA mic...
ORGANISM(S): Homo sapiens 
2012-05-11 | E-GEOD-37934 | biostudies-arrayexpress
GenomicsSTAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs
STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs
PRJNA1495349 | ENA
GenomicsAspartic acid, cysteine, and glutamic acid prevent biofilm formation and disrupt mature biofilms of Candida albicans and Staphylococcus aureus
Aspartic acid, cysteine, and glutamic acid prevent biofilm formation and disrupt mature biofilms of Candida albicans and Staphylococcus aureus
PRJNA1449423 | ENA
MetabolomicsChlorogenic acid alters ileal microbiota and metabolites in broilers under immune stress

Immune stress in broilers can cause severe economic losses, chlorogenic acid is an effective plant extract for alleviating immune stress. This study investigates the effect of chlorogenic acid on the intestinal microbiota and metabolites of broilers under immune stress. 312 broilers were randomly...

2025-06-09 | MTBLS11790 | MetaboLights
MetabolomicsAspSnFR: A Genetically-Encoded Biosensor for Real-Time Monitoring of Aspartate in Live Cells

Aspartate is crucial for nucleotide synthesis, ammonia detoxification and maintaining redox balance via the malate-aspartate-shuttle (MAS). To disentangle these multiple roles of aspartate metabolism, tools are required that measure aspartate concentrations in real time and in live cells. We intr...

2024-08-27 | MTBLS10035 | MetaboLights
ProteomicsExpression profile of Rhodnius prolixus midgut associated-aspartic proteases
Monitoring of expression pattern of Rhodnius prolixus A1 aspartic proteases after their enrichment by pepstatin A affinity chromatography from the anterior midgut tissue.
ORGANISM(S): Rhodnius prolixus (Triatomid bug) 
2024-04-28 | PXD044628 | Pride
A1 aspartic proteases Chagas disease Digestive physiology 
MetabolomicsLarge neutral amino acid levels tune perinatal neuronal excitability and survival
Surprisingly little is known about the critical metabolic changes that neural cells have to undergo during development and how even mild, temporary shifts in this program can influence brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5, a transporter of metabolically-...
2023-03-28 | MTBLS6578 | MetaboLights
TranscriptomicsTranscription profiling of mouse hippocampal slices after NMDA or forskolin-rolipram-0 Mg2+ or bicuculline treatment
Effect of different chemical stimuli (NMDA(N-methyl-D-aspartic acid), forskolin/rolipram/0 Mg, bicuculline) on gene expression after 1 h of stimulation in hippocampal slices
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1184 | biostudies-arrayexpress
ProteomicsMultiple aspartic proteases process PE and PPE proteins on the mycobacterial surface of pathogenic mycobacteria
Mycobacterium tuberculosis is the world’s leading bacterial infectious agent. The absence of an effective vaccine and the rise of multi-drug resistant M. tuberculosis strains emphasize the need to identify novel targets for prevention and intervention strategies. Previously, the M. marinum orthologu...
ORGANISM(S): Mycobacterium marinum ATCC BAA-535 
2026-08-19 | PXD067990 | Pride
Mycobacterium marinum Aspartic acid protease Substrate specificity 
TranscriptomicsIdentification of Murine Uterine Genes Regulated in a Ligand-Dependent Manner by the Progesterone Receptor.
Progesterone (P4) acting through its cognate receptor, the progesterone receptor (PR), plays an important role in uterine physiology. The PR knockout (PRKO) mouse has demonstrated the importance of the P4-PR axis in the regulation of uterine function. To define the molecular pathways regulated by P4...
ORGANISM(S): Mus musculus 
2012-08-06 | E-GEOD-39920 | biostudies-arrayexpress
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