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Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner
Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner
Protein kinase D1 (PRKD1, also referred to as PKD1), has been proposed to undergo autophosphorylation on serine 742 and potentially also on serine 738 in the activation loop of its kinase domain. We used recombinant PKD1 kinase domain to test whether PKD1 is indeed able to undergo autophosphorylatio...
ORGANISM(S): Homo sapiens (Human) 
2019-08-19 | PXD013216 | Pride
Casein kinase 1 (CK1) family members are crucial for ER-Golgi trafficking, calcium signaling, DNA repair, tRNA modifications and circadian rhythmicity. Whether and how substrate interactions and kinase autophosphorylation contribute to these diverse cellular processes and CK1 plasticity remains larg...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2024-07-23 | MSV000095414 | MassIVE
Phagocytosis plays a key role in survival and pathogenicity of Entamoeba histolytica. We have recently demonstrated that an atypical kinase EhAK1 is involved in phagocytosis in this parasite. It is recruited to the phagocytic cups through interaction with EhCaBP1. EhAK1 manipulates actin dynamics by...
ORGANISM(S): Entamoeba histolytica HM-1:IMSS-A 
2018-10-24 | PXD002691 | Pride
CK1 enzymes are conserved, acidophilic serine/threonine kinases with a variety of critical cellular functions; their misregulation contributes to cancer, neurodegenerative diseases, and sleep phase disorders. Here, we describe a new mechanism of CK1 regulation conserved from yeast to human – autopho...
ORGANISM(S): Schizosaccharomyces pombe 927 
2023-07-20 | PXD026766 | Pride
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