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MetabolomicsBacillus subtilis inhibits African swine fever virus infection in vivo and in vitro based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II

African swine fever virus (ASFV) is an infectious disease with a mortality rate of nearly 100% in pigs; however, no safe commercial vaccines or antiviral drugs are currently available, which seriously threatens the global pig industry. Therefore, effective biologicals against ASFV are urgently ne...

2023-11-01 | MTBLS6586 | MetaboLights
Metabolomics2E,4E-decadienoic acid, a novel anti-oomycete agent from co-culture of Bacillus subtilis and Trichoderma asperellum

Phytophthora nicotianae is an oomycete pathogen of global significance threatening many important crops. It is mainly controlled by chemosynthetic fungicides, which endangers ecosystem and human health; thus, there is an urgent need to explore alternatives for these fungicides. In this s...

2022-08-01 | MTBLS5405 | MetaboLights
Metabolomicsengineered bacillus subtilis protect the weaned piglets from ETEC K88 infection
engineered bacillus subtilis protect the weaned piglets from ETEC K88 infection through improving serum metabolites, intestinal imcrobiota, antioxidant and immune activity.
2026-02-23 | MTBLS7587 | MetaboLights
MetabolomicsReducing the use of chemical fertilizers and improving crop salt stress tolerance by acetoin and 2,3-butanediol produced by Bacillus subtilis

Small volatile molecules are considered to play a role in promoting plant growth, with acetoin and 2,3-butanediol being representative examples. In this study, we employed metabolic engineering of Bacillus subtilis to enhance the production of acetoin and 2,3-butanediol, and investigated the...

2025-10-16 | MTBLS13110 | MetaboLights
TranscriptomicsSliding of Bacillus subtilis Natto
Transcriptome comparison of Bacillus subtilis Natto under sliding permissive (0.7% agar) and restrictive (1.5% agar or spo0A mutant strain) conditions. B subtilis Natto wild type cells were grown on the top of LB solid medium with 1.5% and 0.7% agar concentration (samples 1-4). B subtilis Natto wild...
ORGANISM(S): Bacillus subtilis subsp. natto 
2015-08-04 | E-GEOD-43840 | biostudies-arrayexpress
TranscriptomicsProbing the regulatory effects of specific mutations in three major binding domains of the pleiotropic regulator CcpA of Bacillus subtilis
Study the effect of single amino acid point mutations in CcpA at the transcriptome level. Cells were grown in LB with or without 1% glucose and harvested at an OD600 of 0.3 (early exponential phase). Bacillus subtilis strain ccpA::spec carrying pHT304 (empty plasmid), pWH_ccpA_M17R, pWH_ccpA_T62H, o...
ORGANISM(S): Bacillus subtilis 
2015-12-24 | E-GEOD-69575 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression in spo0J mutant and wild-type B. subtilis
We investigated the genome-wide DNA binding of the chromosome partitioning and sporulation protein and ParB family member Spo0J in Bacillus subtilis using chromatin immunoprecipitation and DNA microarrays. We identified ten parS loci to which Spo0J binds, two of which were unexpectedly distant (>1 ...
ORGANISM(S): Bacillus subtilis 
2010-06-11 | E-GEOD-6598 | biostudies-arrayexpress
TranscriptomicsCell envelope metabolism in phosphate limited Bacillus subtilis cells
Investigation of the whole genome expression level changes in phosphate limited Bacillus subtilis wild-type and delta-phoPR cells Investigation of the whole genome expression level changes of wild-type and delta-phoPR Bacills subtilis cells comparing high and low phosphate medium For each sample ana...
ORGANISM(S): Bacillus subtilis 
2011-07-12 | E-GEOD-23164 | biostudies-arrayexpress
ProteomicsMolecular physiological characterization of a high heat resistant spore forming Bacillus subtilis food isolate
Bacterial endospores (spores) are among the most resistant living forms on earth. Spores of Bacillus subtilis A163 show extremely high resistance to wet heat compared to spores of laboratory strains. In this study, we found that spores of B. subtilis A163 were indeed very wet heat resistant and rele...
ORGANISM(S): Bacillus Subtilis 
2021-03-21 | MSV000087080 | MassIVE
TranscriptomicsTranscriptome analysis of Bacillus subtilis salt stress adaptation
Whole-genome microarray technology and state-of-the-art proteomic techniques were applied to provide a global and time-resolved picture of the physiological response of B. subtilis cells exposed to a severe and sudden osmotic up-shift. This combined experimental approach provided quantitative data f...
ORGANISM(S): Bacillus subtilis 
2010-05-19 | E-GEOD-18345 | biostudies-arrayexpress
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