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TranscriptomicsMicroarray to find ATF5 dependent genes in response to proteasome inhibition
Environmental stresses that disrupt protein homeostasis induce phosphorylation of eIF2, triggering repression of global protein synthesis coincident with preferential translation of ATF4, a transcriptional activator of the Integrated stress response (ISR). Depending on the extent of protein disrupti...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-43714 | biostudies-arrayexpress
TranscriptomicsMicroarray to find CHOP dependent genes in response to proteasome inhibition
Environmental stresses that disrupt protein homeostasis induce phosphorylation of eIF2, triggering repression of global protein synthesis coincident with preferential translation of ATF4, a transcriptional activator of the Integrated stress response (ISR). Depending on the extent of protein disrupti...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-43713 | biostudies-arrayexpress
ProteomicsAssembly and substrate engagement mechanism of the bacterial proteasome activator Bpa
Raw spectrum files for HDX performed to probe the temperature dependent assembly of Bpa (bacterial proteasome activator) from Mycobacterium tuberculosis.
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773) 
MSV000099239 | MassIVE
UnknownBacterial proteasome activator bpa (rv3780) is a novel ring-shaped interactor of the mycobacterial proteasome.
Not available
S-EPMC4254994 | biostudies-literature
UnknownSubstrates bind to residues lining the ring of asymmetrically engaged bacterial proteasome activator Bpa.
Not available
S-EPMC11953334 | biostudies-literature
TranscriptomicsWidespread Occurrence of m6A in bacterial mRNA
N6-methyladenosine (m6A) is one of the most abundant modifications in eukaryotic RNA. Recent mapping of m6A methylomes in mammals, yeast, and plants as well as characterization of m6A methyltransferases, demethylases, and binding proteins have revealed regulatory functions of this dynamic RNA modifi...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2015-07-08 | E-GEOD-65347 | biostudies-arrayexpress
TranscriptomicsSpt6 Levels are Modulated by PAAF1 and 26S Proteasome to Regulate the HIV-1 LTR and a Subset of Cellular Genes involved in Cancer.
Effect of PAAF1 and Spt6 knock-down on gene expression. Total RNAs were extracted from HeLa-LTR-Luc cells in which PAAF1 or Spt6 had been knock down by a specific siRNA or HeLa-LTR-Luc cells that had been transfected with a control siRNA (“si Neg”). Differentially expressed genes in PAAF1 knock-down...
ORGANISM(S): Homo sapiens 
2012-05-28 | E-GEOD-32033 | biostudies-arrayexpress
ProteomicsStructural analysis of substrate-bound ATP-independent proteasomal activator Bpa from Mycobacterium tuberculosis
Chemical cross-linking coupled to mass spectrometry using the amine-reactive BS3 reagent was used to study the interaction between the bacterial proteasome inhibitor, Bpa, and its substrate protein, heat shock repressor HspR.
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2025-03-17 | PXD047368 | Pride
Chemical cross-linking  bs3  structural proteomics  bacterial proteasome activator 
TranscriptomicsTight Junction Protein 1 is a Modulator and Biomarker of Proteasome Inhibitor Sensitivity in Multiple Myeloma
Proteasome inhibitors are important chemotherapeutics in the treatment of multiple myeloma, but they are currently used empirically as no markers of sensitivity have been validated. We have identified expression of tight junction protein (TJP) 1 as being associated with sensitivity of plasma cells ...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-52369 | biostudies-arrayexpress
TranscriptomicsMicroarray to find CHOP/ATF5 dependent genes in response to proteasome inhibition
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-43716 | biostudies-arrayexpress
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