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MetabolomicsAnalysis of the human adult urinary metabolome variations with age, body mass index and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. ('Sacurine' data set)

Urine metabolomics is widely used for biomarker research in the fields of medicine and toxicology. As a consequence, characterization of the variations of the urine metabolome under basal conditions becomes critical in order to avoid confounding effects in cohort studies. Such physiological infor...

2017-01-20 | MTBLS404 | MetaboLights
ProteomicsIsolation of the Buchnera aphidicola flagellum basal body complexes from the Buchnera membrane
Buchnera aphidicola is an intracellular bacterial symbiont of aphids and maintains a small genome of only 600 kbps. Buchnera is thought to maintain only genes relevant to the symbiosis with its aphid host. Curiously, the Buchnera genome contains gene clusters coding for flagellum basal body structur...
ORGANISM(S): Buchnera aphidicola str. APS (Acyrthosiphon pisum) 
2021-09-10 | PXD024664 | Pride
Basal body Endosymbiont Buchnera Flagella 
TranscriptomicsLong-noncoding RNAs in basal cell carcinoma
A total of 3 patients with basal cell carcinoma (BCC) and 3 healthy individuals (control; non-lesional skin) were enrolled in the study. Punch biopsies (4 mm) were obtained under local anaesthesia and immediately put in RNAlater (Qiagen, Hilden, Germany) and stored at - 80 °C until RNA extraction. ...
ORGANISM(S): Homo sapiens 
2016-03-29 | E-GEOD-74858 | biostudies-arrayexpress
TranscriptomicsFibroblasts prepared from stroma of basal cell carcinoma in comparison to normal dermal fibroblasts
Adult tissue stem cells are known to participate in cancer formation. Indeed, cells exhibiting markers of embryonic stem cells such as Oct-4 and Nanog were detected in some malignant tumors. In this study we demonstrated that stromal cells prepared from the basal cell carcinoma are able to induce ex...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-MTAB-272 | biostudies-arrayexpress
ProteomicsIdentification of proteins in a Salmonella SPI-1 type III secretion injectisome basal body mutant
We determined the cryo-EM structure of a secretion incompetent PrgH130-392 type III secretion injectisome basal body mutant at 6.3 Å. The map shows no density attributable to the inner rod or needle and the periplasmic gate in a closed conformation. We used LC-MS/MS to idensitfy the constituent prot...
ORGANISM(S): Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
2016-12-19 | PXD005133 | Pride
Salmonella Type iii secretion system Injectisome 
TranscriptomicsThe retinoblastoma gene is targeted for rearrangements in BRCA1-deficient basal-like breast cancer.
Breast tumors from BRCA1 germ line mutation carriers typically exhibit features of the basal-like molecular subtype. However, the specific genes recurrently mutated as a consequence of BRCA1 dysfunction have not been fully elucidated. In this study, we utilized gene expression profiling to molecular...
ORGANISM(S): Homo sapiens 
2012-06-26 | E-GEOD-25307 | biostudies-arrayexpress
TranscriptomicsComparison of the human oocyte to its sister polar body
Clinicians need additional metrics for predicting quality of human oocytes for IVF procedures. Human polar bodies reflect the oocyte transcript profile. Quantitation of polar body mRNAs could allow for both oocyte ranking and embryo preferences in IVF applications. The transcriptome of a polar body ...
ORGANISM(S): Homo sapiens 
2011-10-12 | E-GEOD-32689 | biostudies-arrayexpress
TranscriptomicsCorrelation of global micro RNA expression with basal cell carcinoma subtype
Basal cell carcinomas (BCCs) are the most common cancers in the US. Histologic appearance distinguishes several subtypes, each of which can have a different biologic behavior. In this study global miRNA expression was quantified by high throughput sequencing in nodular BCCs, a subtype that is slow...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-33665 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of microRNA expression in basal cell carcinoma
Perturbations in the expression profiles of microRNAs (miRNAs) have been reported for a variety of different cancers. Basal cell carcinoma (BCC) of the skin has not been systematically evaluated regarding differentially expressed miRNAs. Patients with BCC (n=7) were included in the study. Punch biop...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-GEOD-34535 | biostudies-arrayexpress
TranscriptomicsCAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer (aCGH)
Title: CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer Summary: Breast cancer exhibits clinical and molecular heterogeneity, where expression-profiling studies have identified five major molecular subtypes. The basal-like subtype, expressing basal e...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-12813 | biostudies-arrayexpress
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