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ProteomicsGenome-wide base editor screen identifies regulators of protein abundance in yeast
Proteins are key molecular players in a cell, and their abundance is extensively regulated not just at the level of gene expression but also post-transcriptionally. Here, we describe a genetic screen in yeast that enables systematic characterization of how protein abundance regulation is encoded in ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-11-07 | PXD029363 | Pride
Lc-msms Yeast 
GenomicsDeterminants of base editor efficacy are position-specific
Determinants of base editor efficacy are position-specific
PRJEB44304 | ENA
GenomicsTranscriptome wide edits after split-engineered base editor treatment
Transcriptome wide edits after split-engineered base editor treatment
PRJNA750724 | ENA
GenomicsEliminating genome-wide and transcriptome-wide off-target mutations by base editor
Eliminating genome-wide and transcriptome-wide off-target mutations by base editor
PRJNA690814 | ENA
GenomicsBase editor induced mutation spectrum in GFP, human ATP1a1, human TP53BP1 and murine MyoD
Base editor induced mutation spectrum in GFP, human ATP1a1, human TP53BP1 and murine MyoD
PRJNA850939 | ENA
GenomicsMultiplexed inactivation of endogenous genes by base-editor-mediated multi-stop system
Multiplexed inactivation of endogenous genes by base-editor-mediated multi-stop system
PRJNA779867 | ENA
GenomicsEliminating genome-wide and transcriptome-wide off-target mutations by base editor [tBE_target_genomic_seq]
Eliminating genome-wide and transcriptome-wide off-target mutations by base editor [tBE_target_genomic_seq]
PRJNA692189 | ENA
GenomicsBenchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2
Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2
PRJNA747943 | ENA
GenomicsOne-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids
Recent optimization of CRISPR/Cas9-mediated genome engineering has resulted in the development of base editors that can efficiently mediate C>T and A>G transitions. Combining these genome engineering tools with human adult stem cell (ASC)-derived organoid technology holds promise for disease modelin...
EGAS00001006886 | EGA
Genomics
NGS of RHO base editor
PRJNA990454 | ENA
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