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ProteomicsInhibition of Oligomeric BAX by an Anti-Apoptotic Dimer
BAX is a pro-apoptotic BCL-2 protein that resides in the cytosol as a monomer until triggered by cellular stress to transform into an oligomer that permeabilizes the mitochondria and induces apoptosis. We previously reported the generation of a full-length BAX oligomer (BAXO) that recapitulates pro-...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD049315 | Pride
Bcl-w  bax  bcl-w dimer  bax oligomer  hdx-ms  hydrogen/deuterium exchange mass spectrometry  apoptotic regulation 
UnknownCul5<sup>Wsb2</sup> uses BCL2 proteins as co-receptors to target Bim for degradation.
Not available
S-EPMC12363959 | biostudies-literature
TranscriptomicsTranscription profiling of C57/BL6J mice at various ages post partum vs a common control adult (8 week) testis RNA from the same strain
Testis RNA from C57/BL6J mice at various ages post partum was compared to a common control consisting of adult (8 week) testis RNA from the same strain. This generates a time course showing the activation of genes on the array across the first wave of spermatogenesis, which can then be correlated w...
ORGANISM(S): Mus musculus 
2004-03-02 | E-MEXP-35 | biostudies-arrayexpress
GenomicsMulti-layer dosage compensation of the avian Z chromosome (DNA-seq)
Sex-chromosome dosage represents a challenge for heterogametic species to maintain correct proportion of gene products across chromosomes in each sex. While therian mammals (XX/XY system) achieve near-perfect balance of X-chromosome mRNAs through X-upregulation and X-inactivation, birds (ZZ/ZW syste...
ORGANISM(S): Gallus gallus 
2025-06-30 | E-MTAB-14391 | biostudies-arrayexpress
TranscriptomicsAnalysis of P-body (Dcp1) and Stress Granule (Pbp1) RNA content
Non-membrane-bound compartments such as mRNA processing bodies (PBs) and stress granules (SGs) play important roles in the regulation of gene expression following environmental stresses. Here we perform RIP-seq to determine the RNA interactors of Dcp1 (PB marker) and Pbp1 (SG marker) before and afte...
ORGANISM(S): Saccharomyces cerevisiae 
2021-09-30 | E-MTAB-9096 | biostudies-arrayexpress
TranscriptomicsAnalysis of RIP-seq of Ded1 and eIF4A(Tif1) with and without glucose depletion
The aim of this experiment was to look at RNAs which associate with DEAD-box RNA helicases with and without 10 minutes of glucose starvation.
ORGANISM(S): Saccharomyces cerevisiae 
2021-09-30 | E-MTAB-9095 | biostudies-arrayexpress
MetabolomicsDynamic change of IDO1 activity predicts survival in patients with unresectable stage III NSCLC and chemoradiotherapy

OBJECTIVES: High activity of Indoleamine 2,3-dioxygenase1 (IDO1) in lung cancer patients converts tryptophan (Trp), which is the essential amino acid for T cell metabolism, to kynurenine (Kyn) and consequently suppresses anti-tumor immune responses. We aimed to track the dynamics...

2022-08-05 | MTBLS5267 | MetaboLights
GenomicsAtlas of the chromatin landscape in the developing nervous system of Drosophila melanogaster - ChIPseq and ATACseq - time series of tissue specific neuroblast histone PTMs
In this study, I identify novel regulatory nodes and potential signal transduction pathways that govern neurogenic tissue specification and differentiation. The Drosophila melanogaster central nervous system develops from three columns of neuroectodermal cells that give rise to neural stem cells cal...
ORGANISM(S): Drosophila melanogaster 
2025-10-30 | E-MTAB-15767 | biostudies-arrayexpress
TranscriptomicsGene expression data from human metastatic melanoma tumors that may predict response to RAF265
To determine how mutation of BRAF affected the response to RAF265, we utilized a tumor orthotopic implant model of early passage melanoma tumors in nude mice from a series of 17 patients with advanced metastatic Tumor growth was compared between RAF265 treatment (40 mg/kg, QD) and diluent control gr...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-30812 | biostudies-arrayexpress
TranscriptomicsEffect of miR-650 overexpression on gene expression profile of human monocyte-derived dendritic cells
Transcriptional profiling of human monocyte-derived dendritic cells, comparing cells transfected for 24h with Pre-miR-650 or nonsense control. 2 condition experiment: nonsense control versus miR-650 mimic - 3 biological replicates for each condition and control
ORGANISM(S): Homo sapiens 
2015-05-27 | E-GEOD-69228 | biostudies-arrayexpress
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