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MetabolomicsHorizontal Transfer of Bacteriocin Biosynthesis Genes Requires Metabolic Adaptation To Improve Compound Production and Cellular Fitness

Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread among bacterial isolates and are important genetic determinants of competitive fitness within a given habitat. Staphylococci produce a tremendous diversity of compounds, and the corresponding BGCs are frequen...

2022-11-09 | MTBLS5196 | MetaboLights
MetabolomicsAntioxidant Activity, Phytochemical Profiling by UPLC-QTOF-MS, and In Silico Targeting of the RNA-Binding Protein DRBD18 of Trypanosoma brucei by Bioactive Compounds from Tetradenia riparia and Tetracera poggei
Oxidative stress plays a key role in the pathogenesis of African trypanosomiasis, and plant-derived antioxidants represent a promising source of dual-action compounds capable of both scavenging reactive oxygen species and interfering with parasite survival. The present study investigates the antioxi...
2026-09-10 | MTBLS15597 | MetaboLights
TranscriptomicsTranscription profiling of human osteoblasts differentiated from human mesenchymal stem cells and treated with three bioactive peptides
Effects of bioactive peptides IPP(Ile-Pro-Pro), VPP (Val-Pro-Pro), and LKP(Leu-Lys-Pro) on gene expression of osteoblast differentiated from human mesenchymal stem cells. Experimental design types: compound treatment and augmented reference design.
ORGANISM(S): Homo sapiens 
2008-01-23 | E-MEXP-885 | biostudies-arrayexpress
ProteomicsDeciphering mechanism of actions of novel compounds by bioactive thermal proteome profiling
Exploring the therapeutic effects of bioactive compounds has been traditionally approaching by phenotypic screenings followed by functional validation by in vitro assays. The thermal proteome profiling (TPP) has been successfully applied to study drug targets and off-target. We applied a modified pr...
ORGANISM(S): Homo sapiens (Human) 
2019-06-28 | PXD013227 | Pride
Thermal proteome profiling  mechanism of actions  bioactive compound  label-free quantitative proteomics  marine biodiscovery 
TranscriptomicsBioactive Pyridine-N-oxide Disulfides from Allium stipitatum
In this study, the researchers isolated a colorless waxy solid from the chloroform extract of Allium stipitatum as Compound 1. They demonstrated compound 1 is a potent bactericidal agent against nonreplicating Mycobacterium tuberculosis. Using microarray technology the authors report gene expression...
ORGANISM(S): Mycobacterium tuberculosis 
2009-08-15 | E-GEOD-17640 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of Chromochloris zofingiensis reveals key protein involved in cell growth and bioactive compound biosynthesis
Glucose metabolism regulates cell growth and affects astaxanthin accumulation in green algae Chromochloris zofingiensis. Hub genes function in this bioactive compound biosynthesis has been illustrated in genome, transcriptome and metabolome level, but rather limited from proteome aspects. Microalgal...
ORGANISM(S): Chromochloris Zofingiensis 
2022-06-13 | PXD034488 |
GenomicsVibrio sp. HV10
Produces the bioactive compound kahalalide
PRJNA32095 | ENA
ProteomicsAnalyzing Bioactive Effects of the Minor Hop Compound Xanthohumol C on Human Breast Cancer Cells Using Quantitative Proteomics
We provide label-free data-dependent acquisition proteomics data of mcf-7 breast cancer cell lines treated with the pure minor hop compounds xanthohumol and xanthohumol c.
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD010785 | Pride
Cancer Minor hop compounds Mcf-7 Xanthohumol c Human Lc-ms/ms Bioactivity 
GenomicsBioactive compound from marine sponge-derived Streptomyces sp. SBT348 inhibits staphylococcal growth and biofilm formation
Bioactive compound from marine sponge-derived Streptomyces sp. SBT348 inhibits staphylococcal growth and biofilm formation
PRJNA432515 | ENA
GenomicsSorangium cellulosum So ce56
Bioactive compound producer
PRJNA28111 | ENA
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