Sort   by:  
 Page size 
TranscriptomicsTranscription profiling by array of human amnion epithelial FL cells treated with the carcinogen BPDE at low concentration
The environmental carcinogen, (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), causes bulky-adduct DNA damages, triggers certain signaling pathways, and elicits gene expression changes. Here, we focused on the temporal gene expression changes induced by a low concentration (0.05 µM) BPDE in hum...
ORGANISM(S): Homo sapiens 
2009-01-14 | E-GEOD-10979 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human amnion epithelial FL cells treated with benzo(a)pyrene diol epoxide
Genotoxic agents cause cellular DNA damage and stress responses, including transcriptional changes. Here we focused on the early transcriptional responses of human cells to benzo(a)pyrene diol epoxide (BPDE), which causes bulky DNA adduct damage. Human amnion epithelial FL cells were exposed to thre...
ORGANISM(S): Homo sapiens 
2008-04-08 | E-GEOD-7675 | biostudies-arrayexpress
Transcriptomicsp53 status and BaP or BPDE gene expression response
Human colon carcinoma cells (HCT116) differing in p53 status were exposed to benzo(a)pyrene (BaP) (2.5 and 5 uM for up to 48 h) or anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide (BPDE)(0.5 and 1 uM for up to 24 h), and their gene expression responses compared by cDNA microarray technology. K...
ORGANISM(S): Homo sapiens 
2007-11-13 | GSE9547 | GEO
GenomicsThe effect of BPDE on induced pluripotent stem cells of a Nijmegen Breakage Syndrome patient and healthy donors.
The effect of BPDE on induced pluripotent stem cells of a Nijmegen Breakage Syndrome patient and healthy donors.
PRJNA1120347 | ENA
ProteomicsCanonical autophagy remains inactive in induced pluripotent stem cells and neuronal progenitor cells following DNA damage induced by BPDE or etoposide
(Macro-)Autophagy is a key cellular stress response mediating the recycling of long-lived or damaged proteins and organelles. In stem cells, autophagy is essential for the decision between quiescence, self-renewal and differentiation. We observed that induced pluripotent stem cells (iPSCs) and there...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD066480 | Pride
Autophagy  ipsc  npc  etoposide  bpde 
TranscriptomicsThe effect of BPDE on induced pluripotent stem cells of a Nijmegen Breakage Syndrome patient and healthy donors.
Benzo[a]pyrene diol epoxide (BPDE) is a highly carcinogenic metabolite of the environmental contaminant Benzo[a]pyrene, which is commonly found as a by-product of incomplete combustion of organic matter. BPDE reacts with the DNA to form BPDE-DNA bulky adducts which, if not removed, can lead to mutat...
ORGANISM(S): Homo sapiens 
2025-03-10 | GSE269119 | GEO
TranscriptomicsA study of temporal transcriptional changes induced by a low concentration BPDE in cultured human cells
The environmental carcinogen, (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), causes bulky-adduct DNA damages, triggers certain signaling pathways, and elicits gene expression changes. Here, we focused on the temporal gene expression changes induced by a low concentration (0.05 µM) BPDE in hum...
ORGANISM(S): Homo sapiens 
2009-01-01 | GSE10979 | GEO
UnknownMUC1 contributes to BPDE-induced human bronchial epithelial cell transformation through facilitating EGFR activation.
Not available
S-EPMC3310874 | biostudies-literature
UnknownIntegrated transcriptomics and proteomics reveal ferroptosis induced by B[a]P and BPDE in mouse hippocampal neurons.
Not available
S-EPMC12647577 | biostudies-literature
GenomicsHomo sapiens
p53 status and BaP or BPDE gene expression response
PRJNA103363 | ENA
Sort   by:  
 Page size