Sort   by:  
 Page size 
TranscriptomicsHuman BRAF-V600E melanoma cell lines drug sensitive vs drug resistant
aCGH of human melanoma cell lines comparing parental (drug sensitve) vs isogenic drug resistant-derived subline Two condition experiment: two BRAF-V600E mutant cell lines (drug sensitive - parental baseline) vs two derived sublines after chronic exposure to the MEK inhibitor trametinib (drug resista...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-49430 | biostudies-arrayexpress
MetabolomicsDisruption of Redox Balance Enhances the Effects of BRAF-inhibitors in Melanoma
Not available
ORGANISM(S): Homo sapiens 
ST001339 | MetabolomicsWorkbench
TranscriptomicsAnti-BRAF mutation drug resistance enhances EGFR expression in melanomas [expression profiling]
We treated melanoma cells with BRAF mutation with BRAF inhibitor and screened for BRAF inhibitor resistant cells. We extracted total mRNA from parental cells and resistant cell lines. We compared their expression by carried out Affymetrix Huex 1.0 ST expression array. Two paired parental/derived ce...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-45648 | biostudies-arrayexpress
TranscriptomicsAnti-BRAF mutation drug resistance enhances EGFR expression in melanomas [methylation profiling]
We treated melanoma cells with BRAF mutation with BRAF inhibitor and screened for BRAF inhibitor resistant cells. We extracted DNA from parental cells and resistant cell lines. We compared the DNA methylation via Illumina 450K Methylation Array Bisulphite converted DNA from the 4 specimens was hybr...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-45647 | biostudies-arrayexpress
TranscriptomicsExpression data from BRAF-mutant melanoma cell lines
Melanoma cell lines were assessed for differences in gene expression patterns between the lines sensitive and resistant to BRAF and MEK inhibitor drugs. 22 BRAF-mutant melanoma cell lines were assessed for response to BRAF and MEK inhibitors in a 3 day drug treatment dose response assay. Based on t...
ORGANISM(S): Homo sapiens 
2015-08-26 | E-GEOD-45558 | biostudies-arrayexpress
TranscriptomicsExpression of BRAF inhibitor resistant colon cancer lines
Colon cancer cell lines with partial sensitivity to the BRAF inhibitor PLX4720 were grown in increasing concentration of the drug to develop acquired resistance. Gene expression was performed for comparison of the resistant clones to the parental lines. Colon cancer cell lines with partial sensitiv...
ORGANISM(S): Homo sapiens 
2012-09-15 | E-GEOD-34299 | biostudies-arrayexpress
TranscriptomicsNew compounds triggering endoplasmic reticulum stress exert anti-melanoma effects and overcome BRAF inhibitor resistance
We discovered and developed a new series of molecules (thiazole benzenesulfonamides). HA15, the lead compound of this series, displayed anti-cancerous activity on all tested melanoma cells including those isolated from patients and those that developed resistance to BRAF inhibitors. Our molecule dis...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-79071 | biostudies-arrayexpress
TranscriptomicsSpectrum, clinical correlates and clinical implications of BRAF-inhibitor resistance mechanisms in melanoma
Multiple BRAF inhibitor resistance mechanisms have been described, however their relative frequency, clinical correlates, and effect on subsequent therapy have not been assessed in patients with metastatic melanoma. Excised progressing BRAFV600 mutant melanoma metastases (Prog) from patients treated...
ORGANISM(S): Homo sapiens 
2014-02-19 | E-GEOD-50509 | biostudies-arrayexpress
TranscriptomicsWnt5A Enhances Resistance of Melanoma Cells to Targeted BRAF Inhibitors
About half of all melanomas harbor a constitutively active mutant BRAFV600E/K kinase that can be selectively inhibited by targeted BRAF inhibitors (BRAFi). While patients treated with BRAFi initially exhibit measurable clinical improvement, the majority of patients eventually develop drug resistance...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-55583 | biostudies-arrayexpress
TranscriptomicsRNA-Sequencing of vemurafenib-sensitive and resistant melanoma cell line SKMEL-239
RNA-seq data were generated for two conditions: for parental SK-MEL-239 cells grown in normal media and resistant SK-MEL-239 cells grown in media supplemented with vemurafenib.
ORGANISM(S): Homo sapiens 
2022-04-16 | E-MTAB-11609 | biostudies-arrayexpress
Sort   by:  
 Page size