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TranscriptomicsBovine trophoblasts: control vs. infected with Brucella abortus
Brucellosis is still a widespread zoonotic disease. Very little is known about the interaction between B. abortus and trophoblastic cells, which is essential for better understanding the pathogenesis of the Brucella-induced placentitis and abortion, a key event for transmission of the disease. The g...
ORGANISM(S): Bos taurus 
2010-05-26 | E-GEOD-10342 | biostudies-arrayexpress
ProteomicsLabel-free quantitative proteomic analysis of Brucella abortus and Brucella melitensis
Brucella type strains (B. abortus 544 and B. melitensis 16 M), field-isolates (B. abortus T and B. melitensis C) were independently cultivated six times on Tryptic Soy Broth at 37 °C in the presence of 5% CO2 until mid-logarithmic phase. The cells were harvested by brief centrifugation and the bacte...
ORGANISM(S): Brucella abortus Brucella melitensis 
2020-06-11 | PXD006348 | Pride
Label free quantitative analysis Perseus software Brucella abortus Brucella melitensis Maxquant-andromeda Comparative proteomic analysis Ltq orbitrap velos mass spectrometer Maxquant software 
TranscriptomicsBrucella melitensis global gene expression
In this study we report that B. melitensis at the late logarithmic phase of growth are more invasive for HeLa cells than at mid logarithmic or stationary growth phases. Microarray analysis of B. melitensis gene expression identified 414 up- and 40 down-regulated genes in late-log growth phase compar...
ORGANISM(S): Brucella melitensis 
2010-05-19 | E-GEOD-11192 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide identification of Hfq-associated RNAs in Brucella suis by deep sequencing
We report the identification of new noncoding RNAs in Brucella suis 1330 and that are associated to the chaperone protein Hfq Coimmunoprecipitation using Flag-tagged Hfq as bait
ORGANISM(S): Brucella suis 1330 
2015-11-25 | E-GEOD-73621 | biostudies-arrayexpress
TranscriptomicsTranscripyome analysis of Brucella melitensis 16M and otpR mutant using Solexa/Illumina platform
We sequenced the mRNA of Brucella melitensis 16M and otpR mutant under acid stress to identify genes that were regulated by regulator OtpR. Examination of mRNA levels in individual sample under acid stress.
ORGANISM(S): Brucella melitensis 
2015-08-11 | E-GEOD-48165 | biostudies-arrayexpress
TranscriptomicsMicroarrays of macrophages infected with smooth or rough Brucella suis
The macrophage-Brucella interaction is critical for the establishment of a chronic Brucella infection. Smooth virulent B. suis strain 1330 (S1330) prevents macrophage cell death. However, rough attenuated B. suis strain VTRS1 induces strong macrophage cell death. To further investigate the mechanis...
ORGANISM(S): Mus musculus 
2011-06-24 | E-GEOD-21117 | biostudies-arrayexpress
TranscriptomicsDifferential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection (part 2)
Brucella melitensis and Brucella canis differ by ~75 genes yet B. melitensis is highly virulent for humans while B. canis is considered rarely pathogenic. No identified bacterial factors or mechanisms account for this difference in virulence. To identify functional differences of these two bacteri...
ORGANISM(S): Brucella canis 
2012-12-01 | E-GEOD-34498 | biostudies-arrayexpress
TranscriptomicsThe Brucella abortus general stress response system is required for chronic animal infection and exhibits noncanonical post-translational regulation
rpoE1 encodes an extracytoplasmic function (ECF) sigma factor to initiate the transcription of the genes responsible for general stress responses. This experiment is quantifying transcription in two Brucella strains: B. abortus 2308 wild type and rpoE1 in-frame deletion strains (gene bab1_1672).
ORGANISM(S): Brucella abortus 
2013-05-17 | E-MEXP-3722 | biostudies-arrayexpress
TranscriptomicsPrlR regulon in Brucella melitensis 16M
Investigation of whole genome gene expression level changes in a Brucella melitensis delta prlr mutant compared to the wild type strain. The mutants analyzed in this study are further described in A. Mirabella, R-M Yanez, R.M. Delrue, S. Uzureau, M.S. Zygmunt, A. Cloeckaert, X. De Bolle, J.J. Letess...
ORGANISM(S): Brucella melitensis bv. 1 str. 16M 
2012-12-31 | E-GEOD-34633 | biostudies-arrayexpress
TranscriptomicsDifferential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection (part 4)
Brucella melitensis and Brucella canis differ by ~75 genes yet B. melitensis is highly virulent for humans while B. canis is considered rarely pathogenic. No identified bacterial factors or mechanisms account for this difference in virulence. To identify functional differences of these two bacteri...
ORGANISM(S): Brucella canis 
2012-12-01 | E-GEOD-34503 | biostudies-arrayexpress
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