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MetabolomicsMetabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice
It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5, slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male,...
2018-06-20 | MTBLS667 | MetaboLights
TranscriptomicsExpression data from peritoneal macrophages stimulated with trehalose-6,6'-dimycolate (TDM)
Macrophage-inducible C-type lectin (Mincle, Clec4e) is a pathogen sensor that recognizes pathogenic fungi and Mycobactrium tuberculosis. We perfomed microarray analysis using peritoneal macrophages stimulated with TDM, a mycobacterial cell wall glycolipid that is known to be a Mincle ligand. Many ch...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52338 | biostudies-arrayexpress
ProteomicsProbing the ovarian cancer O-glycoproteome by the Macrophage Galactose like C-type Lectin (MGL): dissecting novel patterns of immune recognition
Glycosylation, the posttranslational linking of sugar molecules to proteins, is notoriously altered during tumor transformation. More specifically in carcinomas, GalNAc-type O-glycosylation, is characterized by biosynthetically immature truncated glycans present on the cancer cell surface which prof...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD017510 | Pride
Ovarian cancer O-glycosylation Cancer immunotherapy Tn antigen Dcs Tumor biomarker 
GenomicsOsteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin
Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin
PRJNA634512 | ENA
GenomicsBLNK negatively regulates C-type lectin receptor-mediated antifungal immunity through inhibiting macrophage migration
BLNK negatively regulates C-type lectin receptor-mediated antifungal immunity through inhibiting macrophage migration
PRJNA1035062 | ENA
GenomicsC-type lectin receptor expression is a hallmark of neutrophils infiltrating the skin in epidermolysis bulls acquisita.
C-type lectin receptor expression is a hallmark of neutrophils infiltrating the skin in epidermolysis bulls acquisita.
PRJNA970330 | ENA
TranscriptomicsTranscription profiling of human monocyte derived dendritic cells treated with DC-SIGN initiates an immature dendritic cell phenotype triggering Rho activation that is utilised by HIV-1
DC-SIGN is a C-type lectin expressed by dendritic cells (DCs) that binds HIV-1, sequestering it within multivesicular bodies to facilitate transmission to CD4+ T cells. Here we characterize the molecular basis of signalling through DC-SIGN by large-scale gene expression profiling and phosphoproteome...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6090 | biostudies-arrayexpress
GenomicsThe protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors
The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors
PRJEB32964 | ENA
TranscriptomicsCharacterization of Nicotiana attenuata plants with reduced expression of lectin receptor kinase 1 (ir-lecRK1 plants).
Identification of transcripts that change expression in Nicotiana attenuata plants with reduced expression of lectin receptor kinase 1 after elicitation with oral secretions of Manduca sexta larvae. Gene expression in leaves of Nicotiana attenuata wild type and ir-lecRK1 plants was measured at 1 hou...
ORGANISM(S): Nicotiana attenuata 
2011-11-23 | E-GEOD-29905 | biostudies-arrayexpress
TranscriptomicsC-type lectin receptor expression is a hallmark of neutrophils infiltrating the skin in epidermolysis bulls acquisita.
Characterization of neutrophil activation from blood to blister in experimental epidermolysis bullosa acquisita: C-type lectin receptors are dispensable in inducing disease.
ORGANISM(S): Mus musculus 
2023-05-11 | GSE231971 | GEO
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