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ProteomicsThe H. pylori CagA Oncoprotein Induces DNA Double Strand Breaks Through Fanconi Anemia Pathway Downregulation and Replication Fork Collapse
The proteins from the Fanconi Anemia (FA) pathway of DNA repair maintain DNA replication fork integrity by preventing the unscheduled degradation of nascent DNA at regions of stalled replication forks. Here, we ask if the bacterial pathogen H. pylori exploits the fork stabilisation machinery to gene...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD031168 | Pride
H. pylori  dna replication  caga  dna double strand breaks  fanconi anemia  h2ax 
TranscriptomicsmicroRNA expression in CagA-expressing cells
Comprehensive analysis of microRNA expression were performed with 238 rat genes of microRNA between CagA-expressing and -non-expressing cells. CagA expression was controlled by tetracycline-off system in RGM1 cells. In the study presented here, RGM1 cells were used to acquire expression profiles of ...
ORGANISM(S): Rattus norvegicus 
2011-04-21 | E-GEOD-27009 | biostudies-arrayexpress
GenomicsmicroRNA expression in CagA-expressing cells
Comprehensive analysis of microRNA expression were performed with 238 rat genes of microRNA between CagA-expressing and -non-expressing cells. CagA expression was controlled by tetracycline-off system in RGM1 cells.
ORGANISM(S): Rattus norvegicus 
2011-04-21 | GSE27009 | GEO
TranscriptomicsTranscription profiling of human gastric epithelial (AGS) cells infected with wild type H. pylori (G27) and isogenic mutants in cagA and vacA for 0, 0.5, 3, 6, and 12 hours
TC1: gastric epithelial (AGS) cells infected with wild type H. pylori (G27) and isogenic mutants in cagA and vacA for 0, 0.5, 3, 6, and 12 hours. Total RNA was used to make single stranded Cy5 labelled probe and compared to Cy3 labelled probe from uninfected AGS cells. Hybridizations of G27 (trial ...
ORGANISM(S): Homo sapiens 
2005-09-30 | E-SMDB-1661 | biostudies-arrayexpress
GenomicsHelicobacter pylori cancer associated CagA protein drives intestinal metaplastic transition in human gastric organoids
Helicobacter pylori cancer associated CagA protein drives intestinal metaplastic transition in human gastric organoids
PRJNA1033174 | ENA
TranscriptomicsHelicobacter pylori cancer associated CagA protein drives intestinal metaplastic transition in human gastric organoids
Gastric intestinal metaplasia (GIM) constitutes a pre-neoplastic stage in the development of stomach cancer. While strong evidence points to a role of infection with CagA positive Helicobacter pylori in the development of GIM, currently available experimental models have not provided mechanistic clu...
ORGANISM(S): Homo sapiens 
2026-08-31 | GSE246474 | GEO
TranscriptomicsHelicobacter pylori colonization ameliorates glucose homeostasis in mice
Background: Helicobacter pylori has been shown to alter the secretion of gastric hormones that modulate body fat deposition. Since cag-positive H. pylori strains interact intimately with the host gastric epithelial cells and trigger higher inflammation than cag-negative strains, we hypothesized that...
ORGANISM(S): Mus musculus 
2010-11-13 | E-GEOD-21833 | biostudies-arrayexpress
TranscriptomicsH. pylori genotypes and host gene expression profiles
H. pylori virulence factors have been suggested to be important in determining the outcome of infection. The H. pylori adhesion protein BabA2 is thought to play an crucial role in bacterial colonization and in induction of a severe gastric inflammation, particularly in combination with expression of...
ORGANISM(S): Homo sapiens 
2008-05-01 | E-GEOD-6143 | biostudies-arrayexpress
GenomicsExpression of genes related to H. pylori infection and its virulence factor CagA, in AGS cells
Expression of genes related to H. pylori infection and its virulence factor CagA, in AGS cells
PRJNA680385 | ENA
UnknownNovel CagA ELISA exhibits enhanced sensitivity of Helicobacter pylori CagA antibody.
Not available
S-EPMC5221286 | biostudies-literature
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