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TranscriptomicsTranscription profiling of human CAL 27 cells overexpressing Nm23-H1 to identify downstream targets of Nm23-H1
The human nm23-H1 was discovered as a tumor metastasis suppressor based on its reduced expression in melanoma cell lines with low versus high metastatic potential. It encodes for one of two subunits of the nucleoside-diphosphate kinase. Besides its role in the maintenance of the cells NTP pool, nm23...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-4069 | biostudies-arrayexpress
TranscriptomicsCAL-51 breast cancer side population cells
Human solid tumors contain rare cancer side population (SP) cells, which expel the fluorescencent dye H33342 and display cancer stem cell characteristics. Transcriptional profiling of cancer SP cells isolated by H33342 fluorescence analysis is a newly emerging approach to discover cancer stem cell m...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-18773 | biostudies-arrayexpress
TranscriptomicsGenes regulated by PCK Inhibitors, enzastaurin and Go, in CAL-27 cells, a SCCHN cell line
Efficacy of the Multi-Kinase Inhibitor Enzastaurin is Dependent on Cellular Signaling Context Testing a panel of SCCHN cell lines revealed variable sensitivity to enzastaurin which correlated significantly with baseline cyclin D1 protein expression. Moreover, sensitivity and resistance could be reve...
ORGANISM(S): Homo sapiens 
2010-07-12 | E-GEOD-22811 | biostudies-arrayexpress
UnknownCAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability.
Not available
S-EPMC3694505 | biostudies-literature
UnknownThe phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia.
Not available
S-EPMC4916562 | biostudies-literature
GenomicsTranscription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells
This SuperSeries is composed of the following subset Series: GSE35910: Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells [EBF1] GSE35914: Transcription factor Ebf1 regulates differentiation stage-specific signaling, prolifer...
ORGANISM(S): Mus musculus 
2012-04-02 | E-GEOD-35915 | biostudies-arrayexpress
GenomicsTranscription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells [EBF1]
Transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into differentiation stage-specific functions of Ebf1, we conditionally inactivated Ebf1. We found that Ebf1 is required for proliferation, survival and signaling of pro-B cells and peripheral B cell su...
ORGANISM(S): Mus musculus 
2012-04-02 | E-GEOD-35910 | biostudies-arrayexpress
UnknownTagging active neurons by soma-targeted Cal-Light.
Not available
S-EPMC9744738 | biostudies-literature
TranscriptomicsCigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD
Chronic obstructive pulmonary disease (COPD) is characterized by a progressive decline in lung function, caused by exposure to exogenous particles, mainly cigarette smoke (CS). COPD pathogenesis is initiated and perpetuated by an abnormal CS-induced inflammatory response of the lungs, involving both...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-52509 | biostudies-arrayexpress
ProteomicsHsa-miR-139-5p expression regulates the abundance of proteins related to poor survival cancer in CAL-62 thyroid cancer cell line
We studied the impact of hsa-miR-139-5p on the protein output by means of an iTRAQ-based approach. First, we established two CAL-62 isogenic cell lines expressing either the mature hsa-miR-139-5p or a non-targeting control upon a doxycycline inducible promoter (PTRE3G-tGFP, Dharmacon). Total protein...
ORGANISM(S): Homo sapiens (Human) 
2019-08-13 | PXD011901 | Pride
Thyroid cancer Cal-62 Hsa-mir-139-5p Impact Itraq 
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