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We studied the impact of hsa-miR-139-5p on the protein output by means of an iTRAQ-based approach. First, we established two CAL-62 isogenic cell lines expressing either the mature hsa-miR-139-5p or a non-targeting control upon a doxycycline inducible promoter (PTRE3G-tGFP, Dharmacon). Total protein...
ORGANISM(S): Homo sapiens (Human) 
2019-08-13 | PXD011901 | Pride
Hsa-miR-139-5p/HNRNPF axis modulates gene-transcripts balance in thyroid cancer cells
We explored alternative splicing events upon hsa-miR-139-5p/HNRNPF axis regulation in our cell system using the Multivariate Analysis of Transcript Splicing (rMATS) computational tool (https://doi.org/10.1073/pnas.1419161111). Differential analysis of major splicing outcomes (skipped exon, alternati...
ORGANISM(S): Homo sapiens 
2019-08-26 | GSE123680 | GEO
Invasive lobular carcinoma (ILC) of the breast accounts for 5-15% of breast cancers and is characterized by loss of E-cadherin and believed to arise via a linear histological progression. Genomic studies have identified a clonal relationship between ILC and concurrent lobular carcinoma in situ (LCIS...
ORGANISM(S): Homo sapiens 
2011-04-11 | GSE28514 | GEO
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