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TranscriptomicsAberrant calcium influx causes fiber type shift and mitochondrial loss in skeletal muscle
Skeletal muscle excitation-contraction (EC) coupling is independent of calcium influx. In fact alternative splicing of the voltage-gated calcium channel CaV1.1 actively suppresses calcium currents in mature muscle. Why this might be necessary is not known. However, splicing defects causing aberrant ...
ORGANISM(S): Mus musculus 
2016-04-01 | E-GEOD-67803 | biostudies-arrayexpress
GenomicsDopaminergic neurons are vulnerable to dysregulation of YEATS2-dependent calcium homeostasis
Dopaminergic neurons are vulnerable to dysregulation of YEATS2-dependent calcium homeostasis
PRJNA1314219 | ENA
UnknownComputational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes.
Not available
S-EPMC5881945 | biostudies-literature
GenomicsUnraveling calcium dysregulation and autoimmunity in immune mediated rippling muscle disease
Unraveling calcium dysregulation and autoimmunity in immune mediated rippling muscle disease
PRJNA1181264 | ENA
GenomicsROS-responsive Nanoparticles for Synergistic Sonodynamic and Calcium Dysregulation Therapy of Endometrial Cancer
ROS-responsive Nanoparticles for Synergistic Sonodynamic and Calcium Dysregulation Therapy of Endometrial Cancer
PRJNA1438729 | ENA
ProteomicsDysregulation of FLVCR1-dependent mitochondrial calcium handling in neural stem cells causes congenital hydrocephalus.
Congenital hydrocephalus (CH), occurring in approximately 1/1000 live births, represents an important clinical challenge due to the limited knowledge of underlying molecular mechanisms. The discovery of novel CH-genes is thus essential to shed light on the intricate processes responsible for ventric...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047897 | Pride
Calcium handling Mass spectrometry Flvcr1 
GenomicsSorbs2 Deficiency Causes Diastolic Dysfunction Through Dysregulation of Cytoskeletal Networks and Calcium Handling
Sorbs2 Deficiency Causes Diastolic Dysfunction Through Dysregulation of Cytoskeletal Networks and Calcium Handling
PRJNA1312112 | ENA
GenomicsCalcium dysregulation is the critical initiator in high dose chloroquine-induced programmed cell death of Plasmodium falciparum
Calcium dysregulation is the critical initiator in high dose chloroquine-induced programmed cell death of Plasmodium falciparum
PRJNA1232628 | ENA
ProteomicsiPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic/lysosomal dysfunction and impaired calcium homeostasis
Mutations in the acid β-glucocerebrosidase (GBA1) gene, responsible for the lysosomal storage disorder Gaucher’s disease (GD), are the strongest genetic risk factor for Parkinson’s disease (PD) known to date. To elucidate the mechanisms underlying neurodegeneration in these patients, we generate...
ORGANISM(S): Homo sapiens (Human) 
2014-06-03 | PXD000866 | Pride
Tmt Neurons Human 
ProteomicsRyR2-mediated calcium leak increases glyoxalase I in the aging brain
Ryanodine receptor 2 (RyR2) mediated chronic calcium leak in the brain has been implicated in patients with late-onset Alzheimer’s disease (LOAD) and from aging macaques, but the direct downstream consequences of calcium leak remain unclear. Here, we present that RyR2 mediated chronic calcium leak l...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-25 | PXD053288 | Pride
Glyoxalase i  ryanodine receptor 2  calcium dysregulation  aging  macaque  prefrontal cortex  hippocampus  proteomics 
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