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MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1969 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1977 | MetaboLights
MetabolomicsMembrane lipid as cofactor of cargo uptake and release by box-like lipid transfer proteins
Lipid transfer proteins (LTPs) shuttle their cargo lipids between cellular membranes. LTPs facilitate the costly extraction of a lipid from a donor membrane, and its delivery into the acceptor membrane, but the mechanisms remain poorly understood. We combined extensive molecular dynamics simulations...
2026-10-06 | MTBLS15933 | MetaboLights
TranscriptomicsBAG6KO impacts extracellular vesicle mRNA cargo
The mRNA cargo of B-16V and B-16V-delta-BAG6 cells was sequenced with RNA seq.
ORGANISM(S): Mus musculus 
2019-11-29 | E-MTAB-7123 | biostudies-arrayexpress
ProteomicsCargo analysis of autophagic bodies in Saccharomyces cerevisiae
Isolated yeast autophagic bodies and the total cell lysate were analyzed by mass spectrometry.
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2024-08-22 | PXD052405 | JPOST Repository
GenomicsCargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers
Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers
PRJNA665693 | ENA
TranscriptomicsRNA-Seq of tissue and plasma extracellular vesicles of breast cancer patients at the time of diagnosis and after the breast surgery
In the current study, we performed deep sequencing analysis of the RNA cargo of plasma EVs collected at the time of diagnosis, during and after the NAC and up to 18 months after the surgery and matched tumor and normal tissues from 35 patients with locally advanced BC, and 30 cancer-free females.
ORGANISM(S): Homo sapiens 
2022-10-24 | E-MTAB-12014 | biostudies-arrayexpress
TranscriptomicsExosome RNA cargo in activated liver stellate cells
Previously we have described the role of liver stellate cell exosomes in triggering macrophage migration and immune activation, we wanted to study what cargo in this exosomes were responsible for such activation. We found a few interesting mRNAs and siRNAs involved in the immune response pathway and...
ORGANISM(S): Homo sapiens 
2022-01-31 | E-MTAB-11373 | biostudies-arrayexpress
GenomicsTracking of Individual Cell Populations by 19F MRI using a "Cargo Internalization Receptor (CIR)" System
Tracking of Individual Cell Populations by 19F MRI using a "Cargo Internalization Receptor (CIR)" System
PRJNA415943 | ENA
ProteomicsSILAC-Tp (12 importins)
Importin-beta family proteins are nucleocytoplasmic transport receptors (NTRs), and they transport most nuclear proteins as their cargoes into and out of the nuclei. Human cells have 20 species of importin-beta family NTRs, of which 10 (importin-beta, transportin-1, -2, -SR, importin-4, -5, -7, -8, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-30 | MSV000080815 | MassIVE
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