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ProteomicsThe β2-subunit of voltage-gated calcium channels inhibits cardiomyocyte hypertrophy through a channel-independent mechanism.
L-type voltage-gated calcium channels (LTCCs) regulate crucial physiological processes in the heart. They are composed of the Cav1 pore-forming subunit and the accessory subunits Cav, Cav2 and Cav. Cav is a cytosolic soluble protein that regulates channel trafficking and activity, but it also exerts...
ORGANISM(S): Rattus norvegicus (Rat) Rattus 
2021-09-09 | PXD016483 | Pride
L-type voltage-gated calcium channels  cav-subunit  cardiac hypertrophy  calpain  cardiomyocytes  calpastatin 
TranscriptomicsCavβ3 contributes to the maintenance of the blood-brain barrier and alleviates symptoms of experimental autoimmune encephalitis
Brain microvascular endothelial cells (BMECs) are part of the blood-brain barrier (BBB). These cells express Cacnb3 transcripts encoding the Cavβ3 protein, which is a subunit of the voltage-gated Ca2+ (Cav) channels. However, potassium depolarization and electrophysiological recordings in BMECs did ...
ORGANISM(S): Mus musculus 
2024-07-16 | GSE268823 | GEO
ProteomicsCrotoxin B from the South American Rattlesnake Crotalus vegrandis Blocks Voltage-Gated Calcium Channels Independent of Its Intrinsic Catalytic Activity
Neurotoxicity following South American Crotalus rattlesnake bite is primarily caused by crotoxin, the most abundant component in their venom. Despite the central role of volt-age-gated calcium channels (CaV) in neurotransmission, direct targetability by crotoxin has been poorly explored. Crotoxin is...
ORGANISM(S): Crotalus vegrandis 
2026-02-02 | PXD070916 | Pride
UnknownExpression and characterization of highly antigenic domains of chicken anemia virus viral VP2 and VP3 subunit proteins in a recombinant E. coli for sero-diagnostic applications.
Not available
S-EPMC3751357 | biostudies-literature
UnknownThe Na/K-ATPase α1 and c-Src form signaling complex under native condition: A crosslinking approach.
Not available
S-EPMC7138855 | biostudies-literature
UnknownCaV channels reject signaling from a second CaM in eliciting Ca2+-dependent feedback regulation.
Not available
S-EPMC7606677 | biostudies-literature
UnknownThe HOOK region of voltage-gated Ca2+ channel β subunits senses and transmits PIP2 signals to the gate.
Not available
S-EPMC5299622 | biostudies-literature
UnknownMultiple Calcium Channel Types with Unique Expression Patterns Mediate Retinal Signaling at Bipolar Cell Ribbon Synapses.
Not available
S-EPMC9410755 | biostudies-literature
UnknownMolecular basis of the PIP2-dependent regulation of CaV2.2 channel and its modulation by CaV β subunits.
Not available
S-EPMC9662827 | biostudies-literature
UnknownFunctional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A.
Not available
S-EPMC5341225 | biostudies-literature
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