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Synovial Sarcoma (SS) is driven by the SS18::SSX fusion oncoprotein and is ultimately refractory to therapeutic approaches. SS18::SSX alters ATP-dependent chromatin remodeling BAF (mammalian SWI/SNF) complexes, leading to the degradation of canonical (cBAF) complex and amplified presence of an SS18:...
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD059936 | Pride
Chromatin binding of RUNX1 in T-cell acute lymphoblastic leukemia (T-ALL) cells with depletion cBAF complex [ChIP-seq]
Chromatin accessibility of T-cell acute lymphoblastic leukemia (T-ALL) cells with depletion or inhbiiton of cBAF complex [ATAC-seq]
Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in synovial sarcoma [SSPDX.RNA-seq]
Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in synovial sarcoma [RNA-seq_Utah]
The Pkm duet: Coordinating C2C12 myoblast proliferation and differentiation through Histone 3 phosphorylation and cBAF complex dynamics
Using ChIP-seq of RUNX1 in the cells with cBAF-targeting gRNA, we identified RUNX1 binding chromain loci which is regulated by cBAF complex
ORGANISM(S): Homo sapiens 
2023-11-04 | GSE243007 | GEO
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