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TranscriptomicsGene expression analysis between CD20- CD138- and CD20+ CD138+ subpopulations using sorted MWCL-1
For the complete cure of tumors, it is essential to eliminate cancer-initiating cells (CICs). Immunohistochemically, most tumor cells were CD20 and/or CD138 positive in clinical samples of lymphoplasmacytic lymphoma (LPL), and CD20- CD138- cells were hardly detected. Therefore, useful positive marke...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-73756 | biostudies-arrayexpress
ProteomicsHDX-MS implicates dynamic CD20 antigen binding to two discontinuous CDR regions in the NCD1.2 monoclonal antibody
A comparative canine-human therapeutics model is being developed in B-cell lymphoma through the generation of a hybridoma cell that produces a murine monoclonal antibody specific for canine CD20. The hybridoma cell produces two light chains, light chain-3 and light chain-7. However, the contribution...
ORGANISM(S): Canis lupus x Canis lupus familiaris 
2021-09-09 | PXD018550 | Pride
Human Comparative medicine Lymphoma Monoclonal antibody Hdx Adept Phage display Cd20 
TranscriptomicsExpression data from human NHL cell lines treated with agonistic antibodies
CD20 is a clinically validated target for Non-Hodgkin’s lymphomas and autoimmune diseases. Interactions of CD20 with the B cell receptor (BCR) and components of the BCR signaling cascade have been reported. In this study we show that antibodies against CD20 or activation of the BCR by specific antib...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-23394 | biostudies-arrayexpress
ProteomicsHydrogen Deuterium Exchange Mass Spectrometry implicates dynamic CD20 antigen binding to two discontinuous CDR regions in the NCD1.2 monoclonal antibody
A comparative canine-human therapeutics model is being developed in B-cell lymphoma through the generation of a hybridoma cell that produces a murine monoclonal antibody specific for canine CD20. The hybridoma cell produces two light chains, light chain-3 and light chain-7. However, the contribution...
ORGANISM(S): Canis lupus x Canis lupus familiaris 
2021-09-09 | PXD018510 | Pride
Human Comparative medicine Lymphoma Monoclonal antibody Hdx Adept Phage display Cd20 Lc-ms/ms 
TranscriptomicsWhole tissue RNA-seq of human melanoma metastasis of patients prior and on anti-CD20 antibody therapy
Eliminating B cells through anti-CD20 antibody led to a drastic reshaping of the inflammatory tumor microenvironment. This included a profound reduction of T cells, endothelial cells, monocytes and fibroblasts. The results of this study are therefore the first evidence in human that B cells are requ...
ORGANISM(S): Homo sapiens 
2019-08-14 | E-MTAB-7473 | biostudies-arrayexpress
TranscriptomicsVariability of gene expression profiles in human blood and lymphoblastoid cell lines
Readily accessible samples such as peripheral blood or cell lines are increasingly being used in large cohorts to characterise gene expression differences between a patient group and healthy controls. However, cell and RNA isolation procedures and the variety of cell types that make up whole blood c...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-30916 | biostudies-arrayexpress
TranscriptomicsSmall molecule inhibitor of BCL2 in combination with RCHOP is effective in CD20 negative lymphoma
Rituximab alone or in combination with chemotherapeutics is the first-line therapy for variety of lymphoproliferative disorders including low- and high grade non-Hodgkin’s lymphomas (NHL). Although the complete response rate is quite impressive, vast majority of patient presents recurrent disease. T...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-54201 | biostudies-arrayexpress
GenomicsmTORC1 inhibition upregulates CD20 and enhances anti-CD20 antibody efficacy in B-ALL
mTORC1 inhibition upregulates CD20 and enhances anti-CD20 antibody efficacy in B-ALL
PRJNA1464731 | ENA
TranscriptomicsCD20+ B cell expression profile
CD20+ B cells were analyzed ex-vivo using to determine technical and biological gene expression variability, in order to design well-powered experiments.
ORGANISM(S): Homo sapiens 
2017-08-15 | E-MTAB-4852 | biostudies-arrayexpress
TranscriptomicsVariation in gene expression patterns in follicular lymphoma and the response to rituximab
This SuperSeries is composed of the following subset Series: GSE3646: Follicular lymphoma and normal lymphoid tissue comparisons GSE3647: Follicular lymphoma lymph node Abstract: Analysis of the patterns of gene expression in follicular lymphomas from 24 patients suggested that two groups of tumors...
ORGANISM(S): Homo sapiens 
2006-03-06 | E-GEOD-4351 | biostudies-arrayexpress
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