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MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
ProteomicsEpitope analysis of the complex of CD73 and HB0039 by HDX-MS
To identify the epitope of the anti-CD73 antibody HB0039 on CD73 antigen
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057868 | Pride
Cd73 hb0039 hdx-ms 
ProteomicsEpitope analysis of the complex of CD73 and HB0038 by HDX-MS
Epitope analysis of the complex of CD73 antigen and the anti-CD73 antibody HB0038 by HDX-MS
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057867 | Pride
Cd73 hb0038 hdx-ms 
GenomicsExpression data from CD73 positive adipose derived mesenchymal stem cells (CD73+ AD-MSCs) and CD73 negative adipose derived mesenchymal stem cells (CD73- AD-MSCs) of mouse
Expression data from CD73 positive adipose derived mesenchymal stem cells (CD73+ AD-MSCs) and CD73 negative adipose derived mesenchymal stem cells (CD73- AD-MSCs) of mouse
PRJNA703950 | ENA
ProteomicsUpregulation of CD73 Confers Acquired Radioresistance and Is Required for Maintaining EMT in the Pancreatic Cancer Cells that Survive Fractionated Irradiation
The molecular mechanisms underlying exceptional radioresistance in pancreatic cancer remain elusive. In the present study, we established a stable radioresistant pancreatic cancer cell line MIA PaCa-2-R by exposing the parental MIA PaCa-2 cells to fractionated ionizing radiation (IR). Systematic pro...
ORGANISM(S): Homo sapiens (Human) 
2019-12-31 | PXD012922 | Pride
Radioresistance Emt Pancreatic cancer Apoptosis Cd73 
TranscriptomicsmiRNA expression data from CD73-positive Rods, Müler glia and E 17.5 Retinal Progenitors
During retinal development, progenitor cells give rise to six different types of neurons, and one glial cell. This process requires the expression of genes that confer specific functions and identity to each cell. Previous works have reported the miRNAs expression profile in retina, but is still nec...
ORGANISM(S): Mus musculus 
2016-02-09 | E-GEOD-62109 | biostudies-arrayexpress
TranscriptomicsThe major diversification of Vγ1.1+ and Vγ2+ thymocytes in mice occurs after commitment to the γδ T-cell lineage
Adult murine gammadelta thymocytes can be divided into two major subsets based on their expression of TCRVgamma1.1 or TCRVgamma2, respectively. gammadelta thymocytes mature through distinct stages characterized by CD24 and CD73 in the following order: immature uncommitted (CD24+CD73-), immature comm...
ORGANISM(S): Mus musculus 
2016-07-28 | E-GEOD-75920 | biostudies-arrayexpress
GenomicsCD73 knockdown effect in pancreatic cancer cell lines
CD73 knockdown effect in pancreatic cancer cell lines
PRJNA480855 | ENA
TranscriptomicsTLR9 deficiency promotes CD73 expression in T cells and diabetes protection in NOD mice
Analyze the effect of TLR9 deficiency on immue cell function at the gene expression level. Our hypothesis was that TLR9 deficiency promotes CD73 expression in T cells thus regulates autoimmune diabetes development in NOD mice. Sorted TCRb+ cells were pooled from several mice for furhter RNA extracti...
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-48781 | biostudies-arrayexpress
TranscriptomicsExpression data from CD73 positive adipose derived mesenchymal stem cells (CD73+ AD-MSCs) and CD73 negative adipose derived mesenchymal stem cells (CD73- AD-MSCs) of mouse
MSCs are a heterogeneous population and the specific population of MSCs may exhibit a selective ability for tissue repair. The aim of our research was to adapt the CD73+ subgroup of adipose derived MSCs (AD-MSCs) for the therapy of myocardial infarction (MI). Our results revealed that CD73+ AD-MSCs ...
ORGANISM(S): Mus musculus 
2021-06-02 | GSE167219 | GEO
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