Radioresistance

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1. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA 2. UPMC Hillman Cancer Center, Pittsburgh, PA, USA 3. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA 4. Department of Neurology, University of North Carolina, Chapel Hill, NC, USA (lab head) (1)
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Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA. (1)
Department of Molecular Medicine, Cornell University, Ithaca, NY 14853 Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853 (1)
Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China (1)
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Environmental Toxicology Graduate Program and Department of Chemistry, University of California, Riverside, CA, 92521-0403, USA (1)
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Laboratory for Cell Biology and Signalling, Rudjer Boskovic Institute, Zagreb, Croatia (1)
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA (1)
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Radiation Oncology Center, Chongqing University Cancer Hospital, Chongqing 400030, China. (1)
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Systems Biology Ireland, University College Dublin (1)
Translational Oncology Research Group, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Scotland, United Kingdom (1)
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Upregulation of CD73 Confers Acquired Radioresistance and Is Required for Maintaining EMT in the Pancreatic Cancer Cells that Survive Fractionated Irradiation

The molecular mechanisms underlying exceptional radioresistance in pancreatic cancer remain elusive. In the present study, we established a stable radioresistant pancreatic cancer cell line MIA PaCa-2-R by exposing the parental MIA PaCa-2 cells to fractionated ionizing radiation (IR). Systematic pro...

ORGANISM(S): Homo sapiens (Human)

2019-12-31 | PXD012922 | Pride

Proteomic signatures of radioresistance: Alteration of inflammation, angiogenesis and metabolism-related factors in radioresistant oesophageal adenocarcinomav

The clinical management of locally advanced oesophageal adenocarcinoma (OAC) commonly involves neoadjuvant chemoradiotherapy (CRT), but complete pathological response to CRT only occurs in 20-30% of patients, as radioresistance remains a major clinical challenge. In this study we used an established...

ORGANISM(S): Homo sapiens (Human)

2022-08-18 | PXD020303 | Pride

Oesophageal adenocarcinoma Oac

USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGFβ2 transcription

PRJNA562502 | ENA

To identify genes for radioresistance in lung cancer

PRJNA655487 | ENA

ISGylation of H2AX retains MDC1 and facilitates homologous recombination repair causing radioresistance in esophageal adenocarcinoma

High expression of interferon-stimulated gene 15 (ISG15) has been associated with poor survival in patients with esophageal adenocarcinoma (EAC). Like ubiquitin, ISG15 utilizes its C-terminal LRGG motif to post-translationally modify target proteins through a process called ISGylation, thereby influ...

ORGANISM(S): Homo sapiens (Human)

2026-04-27 | PXD071548 | Pride

Radioresistance H2ax Esophageal adenocarcinoma. Homologous recombination repair (hrr) Isgylation

To identify genes for radioresistance in lung cancer [CRISPR Screen]

PRJNA1295363 | ENA

USP10-mediated PFKFB4 deubiquitination induces lung cancer radioresistance by activating the fumarate/Rad51 axis

PRJNA1051015 | ENA

miRNAs were involved in the radioresistance of esophageal squamous cell carcinoma

PRJNA513486 | ENA

IQGAP3 bridges matrix stiffness with glioma stem cell maintenance and radioresistance by stabilizing SOX2

Drivers of therapeutic resistance in cancer include evolution of tumor cell heterogeneity and the tumor microenvironment (TME). Here, we found that increased matrix stiffness promotes radioresistance in glioblastoma (GBM) and maintains the tumor cell hierarchy. Differential gene expression revealed ...

ORGANISM(S): Homo sapiens (Human)

2026-02-11 | PXD072748 | Pride

Cancer stem cell Glioma stem cell Glioblastoma Radiation Matrix stiffness Iqgap3 Sox2

IQGAP3 bridges matrix stiffness with glioma stem cell maintenance and radioresistance by stabilizing SOX2

ORGANISM(S): Homo sapiens (Human)

2026-02-11 | PXD072725 | Pride

Cancer stem cell Glioma stem cell Glioblastoma Radiation Matrix stiffness Iqgap3 Sox2

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