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TranscriptomicsDifferentially expressed genes in H2AX knockdown cells undergoing apoptosis
H2AX has been characterized as a novel tumor suppressor protein. Difficiency of H2AX will result in apoptotic inhibition of cancer cells. However, how H2AX epigenetically regulates apoptosis of cancer cells is still unclear. To reveal the genes expression regulated by H2AX and involved in apoptosis,...
ORGANISM(S): Homo sapiens 
2013-01-16 | E-GEOD-43498 | biostudies-arrayexpress
GenomicsWhole-genome landscape of histone H2AX and M-NM-3-H2AX
Phosphorylation of the histone variant H2AX forms M-NM-3-H2AX that marks DNA double-strand break (DSB). Here we generated the sequencing-based maps of H2AX and M-NM-3-H2AX positioning in resting and proliferating cells before and after ionizing irradiation. Genome-wide locations of possible endoge...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-25577 | biostudies-arrayexpress
GenomicsWhole-genome landscape of histone H2AX and γ-H2AX along with related factors in activated cells
Phosphorylation of the histone variant H2AX forms γ-H2AX, which serves as a marker of DNA repair response. Here we provide ChIP-seq-based maps of histone H2AX, γ-H2AX, H2AZ, INO80, SRCAP, and RNA polymerase II in activated T cells. Matched data for H2AX and γ-H2AX in resting T cells and Jurkat ca...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-44309 | biostudies-arrayexpress
GenomicsWhole-genome landscape of histone H2AX and γ-H2AX
Phosphorylation of the histone variant H2AX forms γ-H2AX that marks DNA double-strand break (DSB). Here we generated the sequencing-based maps of H2AX and γ-H2AX positioning in resting and proliferating cells before and after ionizing irradiation. Genome-wide locations of possible endogenous and exo...
ORGANISM(S): Homo sapiens 
2012-04-04 | GSE25577 | GEO
GenomicsWhole-genome landscape of histone H2AX and γ-H2AX along with related factors in activated cells
Phosphorylation of the histone variant H2AX forms γ-H2AX, which serves as a marker of DNA repair response. Here we provide ChIP-seq-based maps of histone H2AX, γ-H2AX, H2AZ, INO80, SRCAP, and RNA polymerase II in activated T cells. Matched data for H2AX and γ-H2AX in resting T cells and Jurkat cance...
ORGANISM(S): Homo sapiens 
2014-04-01 | GSE44309 | GEO
TranscriptomicsChIP-chip profiling of human gammaH2AX spreading around DNA double strand breaks
Chromatin acts as a key regulator of DNA related processes such as DNA damage repair. While ChIP-chip is a powerful technique to provide high-resolution maps of protein-genome interactions, its use to study DNA Double Strand Break (DSB) repair has been hindered by the limitations of the available da...
ORGANISM(S): Homo sapiens 
2010-04-20 | E-MEXP-1769 | biostudies-arrayexpress
TranscriptomicsH2AX controls motor learning and response to oxidative stress
ATM drives DNA repair through rapid phosphorylation of the histone variant H2AX. Similarities between ATM and H2AX are evident in the phenotypes of their knockout mouse models, but the role of H2AX in the brain remains obscure. Here, we provide the first evidence that H2AX loss leads to neurobehavio...
ORGANISM(S): Mus musculus 
2018-03-09 | GSE102548 | GEO
GenomicsHomo sapiens
Whole-genome landscape of histone H2AX and γ-H2AX
PRJNA133889 | ENA
TranscriptomicsDifferentially expressed genes in H2AX knockdown cells undergoing apoptosis
H2AX has been characterized as a novel tumor suppressor protein. Difficiency of H2AX will result in apoptotic inhibition of cancer cells. However, how H2AX epigenetically regulates apoptosis of cancer cells is still unclear. To reveal the genes expression regulated by H2AX and involved in apoptosis,...
ORGANISM(S): Homo sapiens 
2013-01-16 | GSE43498 | GEO
GenomicsDifferentially expressed miRNAs in H2AX knockdown cells undergoing apoptosis
H2AX has been characterized as a novel tumor suppressor protein. Difficiency of H2AX will result in apoptotic inhibition of cancer cells. However, how H2AX epigenetically regulates apoptosis of cancer cells is still unclear To reveal the miRNA expression regulated by H2AX and involved in apoptosis, ...
ORGANISM(S): synthetic construct Homo sapiens 
2015-04-25 | GSE68233 | GEO
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