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MetabolomicsLong-term low-dose ionizing radiation induced chromosome-aberration-specific metabolic phenotype changes in radiation workers

Long-term low-dose ionizing radiation (LLIR) widely exists in human life and has been confirmed to have potential pathogenic effects on cancer and cardiovascular diseases. However, it is technically and ethically unfeasible to explore LLIR-induced phenotypic changes in the human cohort, leading t...

2022-04-07 | MTBLS3854 | MetaboLights
MetabolomicsThe effect of transplanted mouse feces on serum metabolites of recipient mice after ionizing radiation irradiation
Collect feces from mice exposed to ionizing radiation at 1 week, 2 weeks, 3 weeks, and 4 weeks respectively. After treatment with compound antibiotics, transplant the feces of mice irradiated with ionizing radiation, collect serum from recipient mice, and detect the content of metabolites.
2026-09-28 | MTBLS15756 | MetaboLights
MetabolomicsThe Poly (ADP-Ribose) Polymerase inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells
Breast tumors are characterized into different subtypes based on their surface marker expression, which affects their prognosis and treatment. For example, triple negative breast cancer cells (ER-/PR-/Her2-) show reduced susceptibility towards radiotherapy and chemotherapeutic agents. Poly (ADP-ribo...
2016-11-07 | MTBLS337 | MetaboLights
MetabolomicsBerberine alleviates radiation-induced lung injury through promoting microbiota-derived inosine via gut-lung axis

Radiation-induced lung injury (RILI) is a major complication of thoracic radiotherapy. A previous study has indicated an association between berberine (BBR) and reduced incidence of RILI. However, the underlying mechanisms remain unknown. Here we validated the radioprotective role of BBR in mouse...

2025-05-14 | MTBLS12391 | MetaboLights
MetabolomicsFecal Microbiota Transplantation Restores Gut Homeostasis and Enhances ER-Phagy to Mitigate Radiation-Induced Lung Injury

Radiation-induced lung injury (RILI) is a severe side effect of radiation therapy, characterized by lung tissue damage, inflammation, and organ dysfunction. Although fecal microbiota transplantation (FMT) has shown potential in alleviating radiation-induced damage, its underlying mechanisms ...

2026-01-05 | MTBLS12699 | MetaboLights
MetabolomicsMechanism of Blueberry Anthocyanins in Ameliorating Radiation-Induced Intestinal Injury through Gut Microbiota Modulation
Radiation-induced intestinal injury denotes structural and functional impairment of the intestines resulting directly or indirectly from ionising radiation, such as that employed in radiation therapy for malignant tumours in the abdominal or pelvic regions, within the treatment area. It is a prevale...
2026-05-29 | MTBLS14609 | MetaboLights
MetabolomicsTryptophan metabolic disorder in gut-brain axis induces anxiety-like behavior via neuronal pyroptosis in mice exposed to radiofrequency radiation

Radiofrequency radiation (RFR) with specific parameters could alter brain function, yet the underlying mechanisms remain unclear. The gut-brain axis is reported to be important in regulating brain function. Therefore, this study used gut microbiota intervention, regulation of tryptophan metabolit...

2025-09-12 | MTBLS12483 | MetaboLights
MetabolomicsSIRT5 alleviate cardiomyocyte senescence in radiation-induced heart disease via desuccinylation of HADHB

SIRT5 deficiency caused widespread protein hypersuccinylation in cardiac tissue. Succinylation proteomic analysis revealed HADHB as the key SIRT5 target, with lysine 292 (K292) being the dominant succinylation site. Functional studies demonstrated that K292 succinylation impairs HADHB-mediated fa...

2026-03-15 | MTBLS14057 | MetaboLights
MetabolomicsBiogeography shaped the metabolome of the genus Espeletia: a phytochemical perspective on an Andean adaptive radiation
The páramo ecosystem has the highest rate of diversification across plant lineages on earth, of which the genus Espeletia (Asteraceae) is a prime example. The current distribution and molecular phylogeny of Espeletia suggest the influence of Andean geography and past climatic fluctuations on the div...
2018-11-20 | MTBLS445 | MetaboLights
MetabolomicsTryptophan metabolic disorder in gut-brain axis induces anxiety-like behavior via neuronal pyroptosis in mice exposed to radiofrequency radiation

Radiofrequency radiation (RFR) with specific parameters could alter brain function, yet the underlying mechanisms remain unclear. The gut-brain axis is reported to be important in regulating brain function. Therefore, this study used gut microbiota intervention, regulation of tryptophan metabolit...

2025-09-12 | MTBLS12482 | MetaboLights
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