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MetabolomicsSOX2 Drives Esophageal Squamous Carcinoma by Reprogramming Lipid Metabolism and Histone Acetylation Landscape

SOX2 is not only a pioneer transcription factor with critical roles in stem cell function and cell reprogramming but also a potent oncogene for a multitude of squamous cancers. How SOX2 exerts a potent oncogenic activity in squamous lineage is largely unknown. Here we uncovered SOX2 a p...

2025-08-07 | MTBLS7120 | MetaboLights
ProteomicsGenomic rewiring of Sox2 chromatin interaction network during differentiation of ESCs to postmitotic neurons
Cellular differentiation requires cells to undergo dramatic but strictly controlled changes in chromatin organization, transcriptional regulation, and protein production and interaction. To understand the regulatory connections between these processes, we applied a multi-omics approach integrating p...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-04 | PXD016080 | Pride
Differentiation Lc-msms Mouse Neurons Escs 
ProteomicsCompetitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
The pluripotency transcription factor SOX2 is essential for the maintenance of glioblastoma stem cells (GSC), which drive tumor growth and treatment resistance.To understand how SOX2 is regulated in GSCs, we utilized a proteomic approach and identified the E3 ubiquitin ligase TRIM26...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD028933 | Pride
Glioblastoma Trim26 E3 ligase Wwp2 Brain cancer Sox2 
ProteomicsDevelopment of a method for quantitative analysis of in vivo interactions of pluripotency transcription factors Sox2, Oct4, Nanog by mass spectrometry
Protein-protein proximity of core pluripotency transcription factors plays an important role during cell reprogramming. Pluripotent embryonic stem (ES) cell identity is controlled by a trio of transcription factors: Sox2, Oct4, and Nanog. These proteins often bind to closely localized genomic sites....
ORGANISM(S): Homo sapiens (Human) 
2020-01-21 | PXD015756 | Pride
Mass spectrometry Oct4 Proximity utilizing biotinylation Transcription factors Sox2 Pluripotency 
GenomicsAn integrative analysis of the SOX2 response program in glioblastoma
This SuperSeries is composed of the following subset Series: GSE23795: Chip-Seq analysis of Sox2 protein genome-wide DNA binding sites in glioma cancer cells GSE23838: Genes regulated by Sox2 in glioma cancer cell line Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-23839 | biostudies-arrayexpress
GenomicsChip-Seq analysis of Sox2 protein genome-wide DNA binding sites in glioma cancer cells
We report here our results of the genome wide target identification of SOX2 in GBM cells by ChIP-seq analysis. Identification of Sox2 DNA binding site in glioma cancer cells
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-23795 | biostudies-arrayexpress
GenomicsCUT&RUN Targeting c-FOS, c-JUN and SOX2 in neurospheres derived from mouse brain cells
Other than in the development of the brain, SOX2 is essential for the long-term self-renewal of neural stem cells (NSCs). The mechanisms of how SOX2 maintains the stemness of NSCs is not yet understood. We have identified Fos as a downstream target of SOX2, and therefore used CUT&RUN to investigate ...
ORGANISM(S): Mus musculus 
2021-04-01 | E-MTAB-9897 | biostudies-arrayexpress
TranscriptomicsGenes regulated by Sox2 in glioma cancer cell line
Knockdown of Sox2 in LN229 gliomal cancer cells decrease their growth rates in vitro. We used microarrays to detail the global programme of gene expression in Sox2 Knockdown LN229 cells compared with mock knockdown LN229 cells Sox2 knockdown LN229 cells and and mock knockdown LN229 cells were cultur...
ORGANISM(S): Homo sapiens 
2011-01-10 | E-GEOD-23838 | biostudies-arrayexpress
TranscriptomicsSOX2 gene regulates the transcriptional network of oncogenes and affects tumorigenesis of human lung cancer cells
Recent studies demonstrated that cancer stem cells (CSCs) have higher tumorigenesis properties than those of differentiated cancer cells and that transcriptional factor-SOX2 plays a vital role in maintaining the unique properties of CSCs; however, the function and underlying mechanism of SOX2 in car...
ORGANISM(S): Homo sapiens 
2012-08-31 | E-GEOD-36597 | biostudies-arrayexpress
TranscriptomicsNANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells
This SuperSeries is composed of the following subset Series: GSE34904: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 1) GSE34912: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 2) GSE34918: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem...
ORGANISM(S): Homo sapiens 
2012-04-05 | E-GEOD-34921 | biostudies-arrayexpress
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