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ProteomicsQuantitative proteinomics on WWP2 overexpressed human tubular epithelial cells HK-2
WWP2 is a E3 ligase which regulates multiple cellular events, such as stress response, differentiation. WWP2 played physiological role in the distal tubules of the kidneys. Whether WWP2 regulated pathophysiological rol in the proximal tubules is unclear. In the present study, we stably overexpressed...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD048622 | Pride
Human tubular epithelial cells Wwp2 Proteinomics 
ProteomicsUbiquitylation-omics analysis on WWP2 overexpressed mouse tubular epithelial cells (MPTCs)
WWP2 is a E3 ubiquitin ligase which may be implicated in multiple cellular event. WWP2 expressed in the kidneys and its pathological role remain to be elucidated. We performed this ubiquitylation omics analysis on renal tubular epithelial cells which overexpressd WWP2 to study WWP2's potential ubiqu...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD048540 | Pride
Renal tubular epithelial cells Ubiquitylation-omics 
ProteomicsEnzymatic Analysis of WWP2 E3 Ubiquitin Ligase Using Protein Microarrays Identifies Autophagy-Related Substrates
WWP2 is a HECT E3 ligase that targets protein Lys residues for ubiquitination. As a member of the NEDD4 family of E3 ligases, WWP2 is comprised of an N-terminal C2 domain, four central WW domains, and a C-terminal catalytic HECT domain. The peptide segment between the middle WW domains, the 2,3-link...
ORGANISM(S): Escherichia coli 
2022-05-20 | PXD031703 | Pride
Ubiquitination Protein microarray Wwp2 Autophagy receptor Lc-msms 
GenomicsWWP2 Exacerbates Podocyte Injury in Lupus Nephritis through Monoubiquitylating H2A at K119
WWP2 Exacerbates Podocyte Injury in Lupus Nephritis through Monoubiquitylating H2A at K119
PRJNA1330597 | ENA
GenomicsWWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
PRJNA540306 | ENA
ProteomicsUbiquitin ligase WWP2 targets RNA polymerase II in a DNA-PK-dependent transcription shutoff circuitry for DNA repair
DNA double-strand breaks (DSBs) at RNA polymerase II (RNAPII)-transcribed genes lead to inhibition of transcription. DNA protein kinase (DNA-PK) complex plays a pivotal role in transcription inhibition at DSBs by stimulating proteasome-dependent eviction of RNAPII at these lesions. How DNA-PK trigge...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD012606 | Pride
Human 
GenomicsWWP2 Exacerbates Podocyte Injury in Lupus Nephritis through Monoubiquitylating H2A at K119
Lupus nephritis (LN) is featured with podocyte injury and proteinuria. We previously demonstrated that WWP2, an E3 ubiquitin ligase, differentially regulated tubular injury and tubulointerstitial fibrosis. The present study aims to investigate WWP2’s implication in proteinuria and podocyte injury in...
ORGANISM(S): Homo sapiens 
2026-09-09 | GSE308439 | GEO
GenomicsWWP2 regulates Ly6Chigh monocyte infiltration and activity in heart fibrosis
WWP2 regulates Ly6Chigh monocyte infiltration and activity in heart fibrosis
PRJNA813315 | ENA
GenomicsWWP2 MEDIATES THE METABOLIC REPROGRAMMING OF RENAL MYOFIBROBLASTS TO PROMOTE KIDNEY FIBROSIS [ChIP-Seq]
WWP2 MEDIATES THE METABOLIC REPROGRAMMING OF RENAL MYOFIBROBLASTS TO PROMOTE KIDNEY FIBROSIS [ChIP-Seq]
PRJNA1112817 | ENA
GenomicsWWP2 MEDIATES THE METABOLIC REPROGRAMMING OF RENAL MYOFIBROBLASTS TO PROMOTE KIDNEY FIBROSIS [scRNA-seq]
WWP2 MEDIATES THE METABOLIC REPROGRAMMING OF RENAL MYOFIBROBLASTS TO PROMOTE KIDNEY FIBROSIS [scRNA-seq]
PRJNA1008456 | ENA
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