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ProteomicsUbiquitylation-omics analysis on WWP2 overexpressed mouse tubular epithelial cells (MPTCs)
WWP2 is a E3 ubiquitin ligase which may be implicated in multiple cellular event. WWP2 expressed in the kidneys and its pathological role remain to be elucidated. We performed this ubiquitylation omics analysis on renal tubular epithelial cells which overexpressd WWP2 to study WWP2's potential ubiqu...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD048540 | Pride
Renal tubular epithelial cells Ubiquitylation-omics 
ProteomicsMulti-Omics Integration Highlights the Role of Ubiquitination in Endometriosis Fibrosis
In this study, we comprehensively profiled the ubiquitination landscape of endometriosis for the first time. Through proteomics, transcriptomics, and ubiquitylomics analyses of endometrial tissues from two patient cohorts, we uncovered significant dysregulation of ubiquitin-related enzymes and ubiqu...
ORGANISM(S): Homo Sapiens 
PXD036497 |
GenomicsUSP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3 [ChIP-seq]
Ubiquitin-specific protease 7 (USP7) has been implicated in cancer progression and neurodevelopment. However, its molecular targets remain poorly characterized. We combined quantitative proteomics, transcriptomics, and epigenomics to define the core USP7 network. Our multi-omics analysis reveals USP...
ORGANISM(S): Homo sapiens 
2022-11-12 | GSE217658 | GEO
Transcriptomics(RNA-seq) USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3
Ubiquitin-specific protease 7 (USP7) has been implicated in cancer progression and neurodevelopment. However, its molecular targets remain poorly characterized. We combined quantitative proteomics, transcriptomics, and epigenomics to define the core USP7 network. Our multi-omics analysis reveals USP...
ORGANISM(S): Homo sapiens 
2022-11-08 | GSE193019 | GEO
Genomics(ChIP-seq) USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3
Ubiquitin-specific protease 7 (USP7) has been implicated in cancer progression and neurodevelopment. However, its molecular targets remain poorly characterized. We combined quantitative proteomics, transcriptomics, and epigenomics to define the core USP7 network. Our multi-omics analysis reveals USP...
ORGANISM(S): Homo sapiens 
2022-11-08 | GSE193014 | GEO
Genomics(ChIP-seq) USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3
Ubiquitin-specific protease 7 (USP7) has been implicated in cancer progression and neurodevelopment. However, its molecular targets remain poorly characterized. We combined quantitative proteomics, transcriptomics, and epigenomics to define the core USP7 network. Our multi-omics analysis reveals USP...
ORGANISM(S): Homo sapiens 
2022-11-08 | GSE193013 | GEO
UnknownWWP2 deletion aggravates acute kidney injury by targeting CDC20/autophagy axis.
Not available
S-EPMC12126736 | biostudies-literature
UnknownUSP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3.
Not available
S-EPMC9635827 | biostudies-literature
UnknownMulti-omics profiling reveals rhythmic liver function shaped by meal timing.
Not available
S-EPMC10541894 | biostudies-literature
TranscriptomicsUBA1 dependent inflammation in VEXAS is mediated by cGAS-STING
VEXAS (vacuoles, E1, X-linked, autoinflammatory, somatic) is a genetic disease caused by somatic mutations in UBA1, resulting in severe, systemic autoinflammation and hematologic manifestations. UBA1 encodes the E1 ubiquitin-activating enzyme, which is essential for initiating the majority of ubiqui...
ORGANISM(S): Homo sapiens 
2026-09-22 | GSE295539 | GEO
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