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GenomicsGenome-wide Oct4 binding profile in lung cancer A549 cells
Oct4 stemness gene encoding a transcription factor has been shown to overexpress in cancers. However, precise mechanisms of Oct4 relevant to transcriptional reprogramming leading to somatic cancer progression remain unclear. To address the Oct4-mediated transcriptional program in lung cancer, we int...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-58462 | biostudies-arrayexpress
ProteomicsNucleosome binding by the pioneer transcription factor OCT4
The nucleosome is a fundamental unit of chromatin in eukaryotes, and generally prevents the binding of transcription factors to genomic DNA. Pioneer transcription factors overcome the nucleosome barrier, and bind their target DNA sequences in chromatin. OCT4 is a representative pioneer transcription...
ORGANISM(S): Homo Sapiens (human) 
2020-05-13 | PXD019160 | JPOST Repository
TranscriptomicsNANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells
This SuperSeries is composed of the following subset Series: GSE34904: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 1) GSE34912: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 2) GSE34918: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem...
ORGANISM(S): Homo sapiens 
2012-04-05 | E-GEOD-34921 | biostudies-arrayexpress
ProteomicsEndogenous OCT4 interactome in hESC
In two widely-cited OCT4-protein interactome papers, Ding et al. (Ding et al., 2012) used murine ESC nuclear extract to identify OCT4 interactome in nucleus and Pardo et al. (Pardo et al., 2010) used whole cell lysate to identify OCT4 interactome in murine ESCs. In both papers, Benzonase, a genetica...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD033840 | Pride
Oct4 Esc Human 
TranscriptomicsNANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 4)
The transcription factors Nanog, Oct4 and Sox2 are the master regulators of pluripotency in mouse embryonic stem cells (mESCs), however, their functions in human ESCs (hESCs) have not been rigorously defined. Here we show that the requirements for NANOG, OCT4 and SOX2 in hESCs differ from those in ...
ORGANISM(S): Homo sapiens 
2012-04-05 | E-GEOD-34920 | biostudies-arrayexpress
TranscriptomicsReduced Oct4 expression directs a robust pluripotent state with distinct signaling pathway activity and increased Oct4 and Nanog enhancer occupancy
Analysis of Oct4(Pou5f1)-dependent gene expression levels in mouse embryonic stem cells (ESCs). In order to robustly assess changes in gene expression levels orchestrated by the transcription factor Oct4, we used microarrays to profile the transcriptional activity of four ESC lines: Two of these cel...
ORGANISM(S): Mus musculus 
2013-05-03 | E-MTAB-1619 | biostudies-arrayexpress
TranscriptomicsReprogramming to pluripotency is an ancient trait of vertebrate Oct4 and Pou2 proteins
The evolutionary origins of the gene network underlying cellular pluripotency, a central theme in developmental biology, have yet to be elucidated. In mammals, Oct4 is a factor crucial in the reprogramming of differentiated cells into induced pluripotent stem cells. The Oct4 and Pou2 genes evolved f...
ORGANISM(S): Homo sapiens 
2014-03-23 | E-GEOD-21302 | biostudies-arrayexpress
GenomicsOct4 ChIP-seq in Rex1GFPd2 mouse embryonic stem cell line
Chromatin immunoprecipitation using Oct4 antibodies in Rex1GFPd2 mouse ES cells (parental line; E14Tg2a)
ORGANISM(S): Mus musculus 
2014-06-24 | E-MTAB-2490 | biostudies-arrayexpress
GenomicsAcetylated histone H3K56 interacts with Oct4 to promote mouse embryonic stem cell pluripotency
The presence of acetylated histone H3K56 in human embryonic stem cells (ESCs) correlates positively with the binding of Nanog, Sox2 and Oct4 (NSO) transcription factors at their target gene promoters. However, the function of H3K56ac there has been unclear. We now report that Oct4 interacts with K56...
ORGANISM(S): Mus musculus 
2013-06-25 | E-GEOD-47387 | biostudies-arrayexpress
TranscriptomicsDirect Reprogramming of Human Neural Stem Cells by OCT4
Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by ectopic expression of the four transcription factors (OCT4, SOX2, c-MYC, KLF4). We previously reported that Oct4 alone is sufficient to directly reprogram adult mouse neural stem cells (NSCs) to iPS cells....
ORGANISM(S): Homo sapiens 
2010-05-20 | E-GEOD-15355 | biostudies-arrayexpress
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