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TranscriptomicsH2A.Z.1 mono-ubiquitylation antagonizes BRD2 to maintain poised chromatin in ESCs [RNA-seq]
Histone variant H2A.Z occupies the promoters of active and poised, bivalent genes in ESCs to regulate developmental programs, yet how it contributes to these contrasting states is poorly understood. Here, we investigate the function of H2A.Z.1 mono-ubiquitylation (H2A.Z.1ub) by mutation of the PRC1 ...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-53207 | biostudies-arrayexpress
GenomicsH2A.Z.1 mono-ubiquitylation antagonizes BRD2 to maintain poised chromatin in ESCs [ChIP-seq]
Histone variant H2A.Z occupies the promoters of active and poised, bivalent genes in ESCs to regulate developmental programs, yet how it contributes to these contrasting states is poorly understood. Here, we investigate the function of H2A.Z.1 mono-ubiquitylation (H2A.Z.1ub) by mutation of the PRC1 ...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-53206 | biostudies-arrayexpress
GenomicsEngineering of a histone-recognition domain in Dnmt3a alters the epigenetic landscape of ESCs revealing changes in lineage specification and chromosomal stability (ChIP-Seq)
Histone modifications and DNA methylation represent two distinct modes of varying epigenetic landscapes, but whose exact interrelationship remains unclear. Previous studies have shown that histone H3 lysine 4 trimethylation (H3K4me3) inhibits the binding of de novo DNA methyltransferases (Dnmt) thro...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-57574 | biostudies-arrayexpress
TranscriptomicsEngineering of a histone-recognition domain in Dnmt3a alters the epigenetic landscape of ESCs revealing changes in lineage specification and chromosomal stability (RNA-Seq)
Histone modifications and DNA methylation represent two distinct modes of varying epigenetic landscapes, but whose exact interrelationship remains unclear. Previous studies have shown that histone H3 lysine 4 trimethylation (H3K4me3) inhibits the binding of de novo DNA methyltransferases (Dnmt) thro...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-57575 | biostudies-arrayexpress
GenomicsEngineering of a histone-recognition domain in Dnmt3a alters the epigenetic landscape of ESCs revealing changes in lineage specification and chromosomal stability (Bisulfite-Seq)
Histone modifications and DNA methylation represent two distinct modes of varying epigenetic landscapes, but whose exact interrelationship remains unclear. Previous studies have shown that histone H3 lysine 4 trimethylation (H3K4me3) inhibits the binding of de novo DNA methyltransferases (Dnmt) thro...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-57576 | biostudies-arrayexpress
ProteomicseIF4A3 interactome by IP-MS in mouse ESCs
RNA helicases are involved in multiple steps of RNA metabolism to direct their roles in gene expression, yet their functions in pluripotency control remain largely unexplored. Starting from an RNAi screen of RNA helicases, we identified that eIF4A3, a DEAD-box (Ddx) helicase component of the exon ju...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD031362 | Pride
Ip-ms Eif4a3 Escs 
ProteomicsGenomic rewiring of Sox2 chromatin interaction network during differentiation of ESCs to postmitotic neurons
Cellular differentiation requires cells to undergo dramatic but strictly controlled changes in chromatin organization, transcriptional regulation, and protein production and interaction. To understand the regulatory connections between these processes, we applied a multi-omics approach integrating p...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-04 | PXD016080 | Pride
Differentiation Lc-msms Mouse Neurons Escs 
ProteomicsMethylome profiling of SetDB1 deficient ESCs reveals coordinated epigenetic cross-talk during pluripotency
In pluripotent mouse embryonic stem cells (ESCs), SetDB1, which targets up to twenty thousand genomic loci, plays an essential role in regulating various cellular processes, including maintenance of the embryonic stem cell state, differentiation and metabolism. SetDB1 is best known as a chromatin mo...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-20 | PXD074325 | Pride
Embryo Chep Epigenetics Conditional ko Escs Chromatin Setdb1 
TranscriptomicsECAT15-2/Dppa2 deficient ESCs
Many transcription factors and DNA binding proteins play essential roles in the development of organs in which they are highly and/or specifically expressed. Embryonic stem cell (ESC) associated transcript (ECAT) 15-1 and ECAT15-2, also known as developmental pluripotency-associated (Dppa) 4 and Dpp...
ORGANISM(S): Mus musculus 
2011-10-16 | E-GEOD-31581 | biostudies-arrayexpress
TranscriptomicsExpression data from embryonic stem cells (ESCs) and ESC-like cells
The transplantation of ESCs into living recipients causes teratoma formation which accompanies with several biological reactions in both the transplanted cells and recipient. Co-injection of ESCs with somatic cells that influence donor-recipient homogeneity can affect transcriptional profile of tran...
ORGANISM(S): Mus musculus 
2014-06-23 | E-GEOD-58725 | biostudies-arrayexpress
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