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Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
MetabolomicsHepatocyte Differentiation Metabolism
Not available
ORGANISM(S): Homo sapiens 
ST000837 | MetabolomicsWorkbench
MetabolomicsCritical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Shotgun lipidomics assays without inhibition)

During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multi-omics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation....

2023-07-26 | MTBLS6082 | MetaboLights
MetabolomicsCritical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Targeted lipidomics assay without inhibition)

During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multi-omics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation....

2023-07-26 | MTBLS6084 | MetaboLights
MetabolomicsElevated lysophosphatidylcholines during SSRI-induced neural differentiation correlate with early neurodevelopmental symptoms

Background: Selective serotonin reuptake inhibitors (SSRIs) are often prescribed during pregnancy. Yet, epidemiological studies link in-utero SSRI exposure with neurodevelopmental disorders, such as autism and ADHD. The potential molecular mechanisms by which SSRIs impact early n...

2026-04-02 | MTBLS12645 | MetaboLights
MetabolomicsMetabolomic and physiological analysis of bud differentiation in dense apple (Malus × domestica Borkh.) orchards following thinning and reshaping

BACKGROUND: In China, a majority of apple orchards were initially planted under arboriculture. Noteworthy, as the trees age, there is an increase in the number of branches and the degree of orchard depression and deterioration of the canopy light conditions. This phenomenon results in in blockage...

2025-01-20 | MTBLS11951 | MetaboLights
MetabolomicsMetabolomic Profiling of Human Pluripotent Stem Cell Differentiation into Lung Progenitors
Not available
ORGANISM(S): Homo sapiens 
ST002055 | MetabolomicsWorkbench
MetabolomicsCritical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation (Shotgun lipidomics assays after inhibition with FSG67 and Triacsin C)

During megakaryopoiesis, megakaryocytes (MK) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here we adopt a lipid-centric multi-omics approach to create a quantitative map of the MK lipidome during maturation and proplatelet formation....

2023-07-26 | MTBLS6083 | MetaboLights
MetabolomicsLipidomic profiling of Scd1- and Scd2-deficient C2C12 cells during brown adipogenic differentiation with oleic acid supplementation
This study investigated the lipidomic remodeling of Scd1- and Scd2-deficient C2C12 cells during brown adipogenic differentiation. Scd1 or Scd2 knockout cells and corresponding control cells were induced to undergo brown adipocyte-like differentiation for 96 h. To evaluate whether exogenous monounsat...
2026-06-23 | MTBLS14692 | MetaboLights
MetabolomicsButyric acid derived from porcine-derived antioxidant probiotic PGM326 enhances intestinal cell differentiation by promoting oxidative phosphorylation

This study not only identified an efficient host-homologous antioxidant probiotic, PGM326, but also systematically elucidated its mechanism of exerting antioxidant function by synthesizing BA to promote OXPHOS in intestinal epithelial cells, thereby enhancing cell differentiation. This provides a...

2026-02-01 | MTBLS13818 | MetaboLights
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