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Covalent modifications of core histones govern downstream DNA-templated processes such as transcription by altering chromatin structure and function. Previously, we reported that the plant homeodomain protein ALFIN-LIKE 6 (AL6), a bona fide histone reader that preferentially binds trimethylated lysi...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-06-17 | PXD026541 | Pride
In pluripotent mouse embryonic stem cells (ESCs), SetDB1, which targets up to twenty thousand genomic loci, plays an essential role in regulating various cellular processes, including maintenance of the embryonic stem cell state, differentiation and metabolism. SetDB1 is best known as a chromatin mo...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-20 | PXD074325 | Pride
These is a collection of chromatin proteomics experiments that make up the 80 "in-house" biological conditions covered by ProteomeHD (see publication for more details). All experiments use SILAC, resulting in 80 SILAC ratios comparing the impact of various drugs (estradiol, TSA, hydroxytamoxifen, et...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD008888 | Pride
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