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MetabolomicsBMAL1-depletion remodels ceramide metabolism to regulate ferroptosis and sorafenib chemosensitivity in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematologic malignancy with a poor prognosis. We discovered that BMAL1 is a ferroptosis suppressor. Furthermore, it was also found to be overexpressed in AML patients, affecting the cell cycle and promoting tumor cell growth and progression. In this study, we furthe...
2025-01-24 | MTBLS11557 | MetaboLights
TranscriptomicscaArray_golub-00299: Chemosensitivity prediction by transcriptional profiling
In an effort to develop a genomics-based approach to the prediction of drug response, we have developed an algorithm for classification of cell line chemosensitivity based on gene expression profiles alone. Using oligonucleotide microarrays, the expression levels of 6,817 genes were measured in a pa...
ORGANISM(S): Homo sapiens 
2015-05-16 | E-GEOD-68936 | biostudies-arrayexpress
TranscriptomicsGene expression patterns within cell lines are predictive of chemosensitivity
We generated RNA's and measured expression of 40000 genes using spotted cDNA microarrays from the fifty nine publicly available cell lines of the NCI Developmental Therapeutics Program's NCI60 studies and an additional set of seven cell lines for which GI50 compound sensitivity data were available. ...
ORGANISM(S): Homo sapiens 
2008-02-07 | E-GEOD-7947 | biostudies-arrayexpress
ProteomicsCRTAC1 Enhances the Chemosensitivity of Non-Small Cell Lung Cancer to Cisplatin by Eliciting RyR-mediated Calcium Release and Inhibiting Akt1 Expression
Sensitivity to platinum-based combination chemotherapy is associated with a favorable prognosis in the patients of non-small cell lung cancer (NSCLC). Here, our results obtained from analyses of the Gene Expression Omnibus database of NSCLC patients showed that cartilage acidic protein 1 (CRTAC1) pl...
ORGANISM(S): Homo sapiens (Human) 
2023-08-29 | PXD041782 | Pride
Non-small cell lung cancer  chemosensitivity  crtac1  akt1  ca2+ 
TranscriptomicsExpression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential
Claudin-low tumors are a highly aggressive breast cancer subtype with no targeted treatments and a clinically documented resistance to chemotherapy. They are significantly enriched in cancer stem cells (CSCs), which makes claudin-low tumor models particularly attractive for studying CSC behavior and...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-62230 | biostudies-arrayexpress
TranscriptomicsOvarian Cancer Dataset
Background. Genome-wide expression changes are associated with development of chemoresistance in patients with ovarian cancer (OVCA); the BCL2 antagonist of cell death (BAD) apoptosis pathway may play a role in clinical outcome. Methods. We analyzed specimens and/or genomic data from 1,406 patients...
ORGANISM(S): Homo sapiens 
2011-10-02 | E-GEOD-23554 | biostudies-arrayexpress
GenomicsActivating NOTCH1 mutations increase T-ALL cells’ chemosensitivity by altering PREX2-AKT pathway
Activating NOTCH1 mutations increase T-ALL cells’ chemosensitivity by altering PREX2-AKT pathway
PRJNA743671 | ENA
TranscriptomicsMicroarray Analysis of chemosensitivity in Laryngeal Squamous Cell Carcinoma
OBJECTIVE: To investigate the differentially expressed genes related to the chemosensitivity of laryngeal squamous cell carcinoma （LSCC）by microarrays arrays. METHODS: 1. A total number of 11 patients who underwent induction chemotherapy for primary hypopharyngeal squamous cell carcinoma (7 pa...
ORGANISM(S): Homo sapiens 
2016-08-16 | E-GEOD-85607 | biostudies-arrayexpress
TranscriptomicscaArray_golub-00299: Chemosensitivity prediction by transcriptional profiling
In an effort to develop a genomics-based approach to the prediction of drug response, we have developed an algorithm for classification of cell line chemosensitivity based on gene expression profiles alone. Using oligonucleotide microarrays, the expression levels of 6,817 genes were measured in a pa...
ORGANISM(S): Homo sapiens 
2015-05-16 | GSE68936 | GEO
GenomicsDAZAP2 controls cancer cell chemosensitivity by orchestrating the p53 response upon DNA damage
DAZAP2 controls cancer cell chemosensitivity by orchestrating the p53 response upon DNA damage
PRJNA645200 | ENA
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