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ProteomicsProteomic profiling of CLDN6-deficient germ cell tumor cells
Representing a crucial factor during cell adhesion, polarity, proliferation and migration, the transmembrane protein claudin 6 (CLDN6) has been shown to be a putative target for the treatment of germ cell tumors (GCT). Particularly seminoma (SE), embryonal carcinoma (EC), and choriocarcinoma (CC) in...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD066158 | Pride
Germ cell tumor Seminoma Embryonal carcinoma Choriocarcinoma Yolk-sac tumor Cldn6 
GenomicsIdentification of CLDN6 as a novel tumor-promoting gene in gastric cancer
Identification of CLDN6 as a novel tumor-promoting gene in gastric cancer
PRJNA544946 | ENA
TranscriptomicsIdentification of CLDN6 as a novel tumor-promoting gene in gastric cancer
We identified CLDN6 as a novel tumor-promoting gene in gastric cancer (GC). To clarify the mechanism of tumor promoting by CLDN6, we analyzed the transcriptomic difference between control and CLDN6 knockdown GC cells.
ORGANISM(S): Homo sapiens 
2020-06-01 | GSE131787 | GEO
UnknownPreclinical Efficacy of the Antibody-Drug Conjugate CLDN6-23-ADC for the Treatment of CLDN6-Positive Solid Tumors.
Not available
S-EPMC10233360 | biostudies-literature
GenomicsSpatial transcriptomic analysis of CLDN6-positive solid and small cluster areas in human ovarian cancer
Spatial transcriptomic analysis of CLDN6-positive solid and small cluster areas in human ovarian cancer
PRJNA1412499 | ENA
UnknownCLDN6 promotes chemoresistance through GSTP1 in human breast cancer.
Not available
S-EPMC5678781 | biostudies-literature
UnknownCLDN6 induces chemoresistance through protective autophagy in breast cancer.
Not available
S-EPMC12435484 | biostudies-literature
OtherSpatial transcriptomic analysis of CLDN6-positive solid and small cluster areas in human ovarian cancer
To investigate the intratumoral heterogeneity of CLDN6 expression in epithelial ovarian cancer (EOC), we performed spatial transcriptomic analysis on clinical specimens. CLDN6-positive cells were observed to form two morphologically distinct patterns: solid tumor areas and dispersed small tumor cell...
ORGANISM(S): Homo sapiens 
2026-01-30 | GSE317400 | GEO
UnknownCLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy.
Not available
S-EPMC10026481 | biostudies-literature
UnknownCLDN6 triggers NRF2-mediated ferroptosis through recruiting DLG1/PBK complex in breast cancer.
Not available
S-EPMC11845765 | biostudies-literature
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