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TranscriptomicsTranscription profiling of mouse brain after twelve week treatment with the antipsychotics Clozapine and Haloperidol
Atypical antipsychotic Clozapine has a superior antipsychotic and antimanic effects compared to other antisphicotics. Its widespread use was limited by the side effects of agranulocytosis, cardiomyopathy and metabolic anomalies such as weight gain, and diabetes. Very little is known about mechanisms...
ORGANISM(S): Mus musculus 
2009-02-07 | E-GEOD-6467 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain from animals treated for 4 weeks with the antipsychotics Clozapine and Haloperidol
Atypical antipsychotic Clozapine has a superior antipsychotic and antimanic effects compared to other antisphicotics. Its widespread use was limited by the side effects of agranulocytosis, cardiomyopathy and metabolic anomalies such as weight gain, and diabetes. Very little is known about mechanisms...
ORGANISM(S): Mus musculus 
2009-04-30 | E-GEOD-6511 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain treated with clozapine and haloperidol
This SuperSeries is composed of the following subset Series:; GSE6467: Twelve weeks expression data of the antipsychotics Clozapine and Haloperidol in the mouse brain (Affymetrix, GCRMA). GSE6511: Four weeks expression data of the antipsychotics Clozapine and Haloperidol in the mouse brain (Affymetr...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6512 | biostudies-arrayexpress
ProteomicsToxicoproteomics reveals an effect of Clozapine on autophagy in human liver spheroids
Clozapine is an atypical antipsychotic drug for treatment-resistant schizophrenia. Its side effects, including liver enzyme abnormalities, experienced by many patients preclude a more common use as a first-line therapy of schizophrenia. Toxicoproteomics approaches have been demonstrated to effective...
ORGANISM(S): Homo sapiens (Human) 
2022-12-09 | PXD034257 | Pride
Drug-induced liver injury  data-independent acquisition  clozapine  proteomics  systems toxicologydrug-induced liver injury  data-independent acquisition  clozapine  proteomics  systems toxicology 
ProteomicsProteome analysis of PC12 cells reveals alterations in translation regulation and actin signalling induced by clozapine
Although antipsychotics are routinely used in the treatment of schizophrenia for last decades, their precise mechanism of action is still unclear. In this study we investigated changes in PC12 cells’ proteome under the influence of clozapine, risperidone and haloperidol to identify protein pathways ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-08 | PXD014422 | Pride
Proteome Clozapine Translation Actin signalling Mtor 
GenomicsClozapine reverses dysfunction of glutamatergic neurons derived from clozapine-responsive schizophrenia patients
clozapine and schizophrenia patient-derived neurons
PRJEB50039 | ENA
UnknownClozapine prescribing: comparison of clozapine dosage and plasma levels between White British and Bangladeshi patients.
Not available
S-EPMC8058897 | biostudies-literature
GenomicsDifferential methylation in patients treated with clozapine
Differential methylation in patients treated with clozapine
PRJNA809081 | ENA
ProteomicsToxicoproteomics reveals an effect of Clozapine on autophagy in human liver spheroids
Clozapine is an atypical antipsychotic drug used to treat treatment-resistant schizophrenia. Its side effects, including liver enzyme abnormalities, experienced by many patients preclude its more common use as a first-line therapy for schizophrenia. Toxicoproteomic approaches have been demonstrated ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-13 | PXD038007 | Pride
Drug-induced liver injury  data-independent acquisition  clozapine  proteomics  systems toxicology 
UnknownThe time has come for revising the rules of clozapine blood monitoring in Europe. A joint expert statement from the European Clozapine Task Force.
Not available
S-EPMC11822956 | biostudies-literature
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