Sort   by:  
 Page size 
MetabolomicsAn LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs

INTRODUCTION: Noise-induced hearing loss (NIHL) is an increasing problem in society and accounts for a third of all cases of acquired hearing loss. NIHL is caused by formation of reactive oxygen species (ROS) in the cochlea causing oxidative stress. Hydrogen gas (H2) ...

2021-10-06 | MTBLS2418 | MetaboLights
TranscriptomicsRat Normal Cochlear Nucleus
The cochlear nucleus is the first central pathway involved in the processing of peripheral auditory activity. It is heterogeneous in neuronal populations and physiologic responses and is organized in three major subdivisions: the anterior ventral cochlear nucleus (AVCN), the posterior ventral cochl...
ORGANISM(S): Rattus norvegicus 
2005-12-31 | E-GEOD-3628 | biostudies-arrayexpress
ProteomicsIsolation and Comprehensive Analysis of Cochlear Tissue-derived Small Extracellular Vesicles
Label-free quantitative proteomics analysis of CDsEVs, with the same amount of protein of cochlear tissues used as the control
ORGANISM(S): Mus Musculus 
PXD056591 |
ProteomicsQuantitative Proteomics of Cochlear Tissues: Bilateral Comparisons in Guinea Pigs and Rats
The cochlea, a sensitive biosensor, detects sound waves and converts them into electrical signals the brain recognizes as sound. Damage to cochlear hair cells can release proteins, triggering biological responses that may impair hearing. Mass spectrometry-based proteomics offers insights into protei...
ORGANISM(S): Cavia porcellus (Guinea pig) Rattus norvegicus (Rat) 
2025-07-21 | PXD059025 | Pride
Mass-spectrometry Cochlear tissue Rat Proteomics Guinea pigs 
TranscriptomicsTranscription profiling of mouse with unilateral cochlear removal in Cochlear Nucleus at P7 and P21
Deprivation of peripheral nerve input by cochlear removal in young mice results in dramatic neuron death in the cochlear nucleus (CN). The same manipulation in older mice does not result in significant loss. The molecular basis of this critical period of vulnerability remains largely unknown. Her...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5394 | biostudies-arrayexpress
TranscriptomicsMicroRNAs Involved in Aging of the Lateral Wall of the Cochlear Duct
Age-related hearing loss is a progressive sensorineural hearing loss that occurs as people get older. Degeneration of the organ of Corti and atrophy of the lateral wall of the cochlear duct (or scala media) in the inner ear are the two primary causes. MicroRNAs (miRNAs), a class of short non-coding ...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-57782 | biostudies-arrayexpress
TranscriptomicsIntrinsic regenerative potential of murine cochlear supporting cells
P3 Math1-nGFP mouse cochlear sensory epithelia, consisting of greater and lesser epithelial ridges (GER & LER) including the organ of Corti with nGFP-positive hair cells, were dissected, dissociated into single cells, and labeled with propidium iodide and three CD marker antibodies. The cell suspen...
ORGANISM(S): Mus musculus 
2014-10-22 | E-GEOD-62582 | biostudies-arrayexpress
TranscriptomicsTemporal profiling of gene expression in cochleae of wild type and alpha9 null mice
Efferent inhibition of cochlear outer hair cells is mediated by nicotinic cholinergic receptors containing alpha9 (a9) and alpha10 subunits. Mice lacking a9 nicotinic subunits fail to exhibit classic olivocochlear responses and are characterized by abnormal synaptic morphology at the base of outer ...
ORGANISM(S): Mus musculus 
2010-03-06 | E-GEOD-18567 | biostudies-arrayexpress
ProteomicsUnraveling the Molecular Landscape of Lead-Induced Cochlear Synaptopathy: A Quantitative Proteomic Analysis
This study investigates how lead exposure triggers cochlear synaptopathy and hearing loss in mice. Young-adult CBA/J mice were given lead acetate in drinking water for 28 days. We assessed hearing thresholds, outer hair cell activity, and synaptic changes in the cochlea. Lead exposure raises hearing...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD050415 | Pride
Pb Mouse Hearing loss Cochlea Lc-ms/ms 
UnknownPerilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs.
Not available
S-EPMC5560723 | biostudies-literature
Sort   by:  
 Page size