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TranscriptomicsTranscription profiling of cochleae from young and middle aged mice subjected to calorie restriction to examine age-related changes and calorie restriction-induced changes in gene expression in the cochlea.
Presbycusis is characterized by an age-related progressive decline of auditory function, and arises mainly from the degeneration of hair cells or spiral ganglion (SG) cells in the cochlea. Here we show that caloric restriction suppresses apoptotic cell death in the mouse cochlea and prevents late on...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4786 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse age-related hearing loss cochlea in DBA/2J
Age-related hearing loss (AHL) is the progressive loss of auditory function with aging. The DBA/2J (DBA) mice have been used as a model of AHL and undergoes progressive, age-related hearing loss by 12 weeks of age. Here we analyzed cochlear gene expression of 7-week-old and 36-week-old DBA mice usin...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6045 | biostudies-arrayexpress
TranscriptomicsDeafness Gene Expression Patterns in the Mouse Cochlea Found by Microarray Analysis
This study demonstrates the baseline data of gradient gene expression in the cochlea. Especially for genes whose mutations cause autosomal dominant non syndromic hearing loss (Pou4f3, Slc17a8, Tmc1, and Crym) as well as genes important for cochlear function (Emilin-2 and Tectb), gradual expression c...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-53863 | biostudies-arrayexpress
ProteomicsProteome Comparison of Different-Aged Cochlea
Our work describes the application of mass spectrometry-based label-free quantitative proteomics for the identification of differentially expressed proteins between different-aged cochlea. We report proteins exclusively present as well as up- and downregulated in the cochlear sensory epithelium at ...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-29 | PXD001973 | Pride
Cochlea Proteomics Sensory epithelium Development Quantitative mass spectrometry 
TranscriptomicsExpression data of mice cochlea treated with L-methionine and valproic acid.
Treatment of DBA/2J mice with a combination of L-methionine and valproic acid significantly attenuated progressive hearing loss. We examined gene expression in the whole cochlea of the mice. This study was aimed to detect genes of which change in expression levels were associated with attenuation of...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-62173 | biostudies-arrayexpress
TranscriptomicsExpression data from proximal, middle, and distal segments of E6.5 chicken cochlea
Precise frequency discrimination is a hallmark of auditory function in birds and mammals. In the cochlea, tuning and spectral separation result from longitudinal differences in basilar membrane stiffness and numerous individual gradiations in sensory hair cell phenotypes, but it is unknown what pat...
ORGANISM(S): Gallus gallus 
2014-04-18 | E-GEOD-56888 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat organ of Corti (OC), modiolus (MOD) and stria vascularis (SV) of newborns
The aim of this study was to characterize the basal expression of OC, MOD and SV of newborn rats (3-5 day old) and its changes by short–term cultivation (24 hrs) and mild hypoxia (5 hrs). Three varieties of tissue samples were analyzed (i) Freshly prepared tissue, used as control; (ii) cultures he...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5446 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cochlea to investigate the role of mtDNA mutations in age-related hearing loss in mice carrying a mutator DNA polymerase gamma
Mitochondrial DNA (mtDNA) mutations may contribute to aging and age-related disorders. Previously, we created mice expressing a proofreading-deficient version of the mtDNA polymerase gamma (Polg) which accumulate age-related mtDNA mutations and display premature aging. Here we performed microarray g...
ORGANISM(S): Mus musculus 
2008-11-07 | E-GEOD-4866 | biostudies-arrayexpress
TranscriptomicsAffymetrix microarray analysis- Mouse postnatal day cochlea Bbs8 knockout vs Wildtype
RNA was extracted from two Bbs8+/+ and two Bbs8-/- P0 cochlea on separate days allowing for duplicate biological replications of each microarray experiment. RNA was extracted as described previously using the RNAqueous®-Microkit (Ambion). Total RNA was further purified on an RNAeasy column (Qiagen) ...
ORGANISM(S): Mus musculus 
2015-02-27 | E-MTAB-3165 | biostudies-arrayexpress
TranscriptomicsExpression data of miRNA from mice cochlea during aging
To identify which miRNAs are involved in the onset and progression of age-related hearing loss in the mammalian cochlea We used miRNA microarrays to screen the miRNAs which exhibit the drastic changes in their expressing level during the aging of the cochlea The organ of Corti (OC), the major pathol...
ORGANISM(S): Mus musculus 
2013-03-12 | E-GEOD-45026 | biostudies-arrayexpress
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