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TranscriptomicsGene expression profiling in rat renal allografts after prolonged cold ischemia
Ischemia/reperfusion injury (IRI) has a major impact on the long-term outcome of renal allografts. However, the mechanisms of IRI related to chronic allograft nephropathy (CAN) are still poorly understood. To address this issue, in a F344 to Lewis transplantation model of the rat, kidneys were eithe...
ORGANISM(S): Rattus norvegicus 
2010-06-25 | E-GEOD-4441 | biostudies-arrayexpress
MetabolomicsUntargeted Metabolomics Reveals a Mild Impact of Remote Ischemic Conditioning on the Plasma Metabolome and α-Hydroxybutyrate as a Possible Cardioprotective Factor and Biomarker of Tissue Ischemia
Remote ischemic conditioning (RIC) is a maneuver by which short non-lethal ischemic events are applied on distant organs or limbs to reduce ischemia and reperfusion injuries caused by e.g. heart attacks. As RIC can be induced using a simple blood pressure cuff e.g. prior to revascularization, it con...
2016-12-20 | MTBLS414 | MetaboLights
MetabolomicsIntraoperative intestinal ischemia-reperfusion injury aggravates postoperative delirium by remodeling gut microbiota
Postoperative delirium, is a notable and serious complication after surgery, commonly extending hospitalization by 2-3 days. In a cohort of 167 patients, elevated serum intestinal fatty acid binding protein (I-FABP) was identified as an independent risk factor for postoperative delirium. Complementa...
2026-03-30 | MTBLS14186 | MetaboLights
MetabolomicsMongolian medicine Wulanwendusu-11 ameliorates myocardial ischemia-reperfusion injury in association with the modulation of intestinal microbiota and associated metabolic pathways

Abstract

Objective: Wulanwendusu-11 (WLWDS-11), a traditional Mongolian medicinal formula, is commonly used for the treatment of Cardiovascular diseases. However, its therapeutic material basis and in vivo metabolic profile in the context of chronic myocardial ischemia-reperfusion injury (M...

2025-11-22 | MTBLS13370 | MetaboLights
TranscriptomicsTranscription profiling of rat heart transplants from Lewis to Lewis and Lewis to F344 strains with and without cold storage / prolonged cold ischemia.


Annual heart allograft failure in humans rates about 3-5%. The main reason after the first postoperative year is chronic rejection. Myointimal hyperplasia, the hellmark of chronic rejection, results in a specific type of ischemic heart disease. The lack of angina pectoris symptoms allow vent...
ORGANISM(S): Rattus norvegicus 
2010-10-13 | E-MEXP-2301 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Regulation during murine in vivo heart ischemia comparing wildtype and Per2 deficient mice
Disruption of peripheral circadian rhyme pathways dominantly leads to metabolic disorders. Studies on circadian rhythm proteins in the heart indicated a role for Clock or Per2 in cardiac metabolism. In fact, Per2-/- mice have larger infarct sizes with a deficient lactate production during myocardial...
ORGANISM(S): Mus musculus 
2013-08-21 | E-GEOD-45818 | biostudies-arrayexpress
TranscriptomicsGene expression signatures of ischemia on porcine kidney
Using an oligonucleotide microarray we performed differential transcriptomic analysis of porcine kidneys subjected to intense ischemic stress which could be observed in donors deceased after circulatory death situation (60 min warm ischemia then 24h of cold storage in University of Wisconsin solutio...
ORGANISM(S): Sus scrofa 
2016-03-22 | E-GEOD-79418 | biostudies-arrayexpress
TranscriptomicsMature and aged Male and female rabbit heart gene expression in global ischemia and cardioplegia
Background: Demographic studies have shown that the mean age of patients requiring coronary artery bypass surgery (CABG) is 68 years with approximately 44% of these patients being female . In recent studies, women have been shown to have a significantly greater operative risk as compared to men an...
ORGANISM(S): Oryctolagus cuniculus 
2011-06-28 | E-GEOD-30261 | biostudies-arrayexpress
GenomicsLung transplantation-induced cold ischemia–reperfusion injury in the murine lung
Lung transplantation-induced cold ischemia–reperfusion injury in the murine lung
PRJNA924286 | ENA
MetabolomicsSuccinate accumulation drives ischaemia-reperfusion injury during organ transplantation
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient. Despite its widespread use, our understanding of the m...
2019-09-20 | MTBLS1085 | MetaboLights
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