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Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancer-related death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and indu...
2017-02-09 | MTBLS240 | MetaboLights
Gene expression analysis of 1,2-dimethylhydrazine (DMH)-induced colon cancer in F344 rats. 9 tumours and their paired normal mucosa were hybridized on 4x44K Agilent Whole rat arrays.
ORGANISM(S): Rattus norvegicus 
344 rats were treated twice, one week apart, with subcutaneous injections of 1,2-dimethylhydrazine (150 mg/kg x 2). Thirty-two weeks after the first DMH injection, rats were sacrificed and colonic tumours (T) and normal colon mucosa (NM) harvested and stored in RNAlater. Genomic DNA was extracted f...
ORGANISM(S): Rattus norvegicus 
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