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MetabolomicsThe lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression
Abnormalities in ether lipid metabolism as well as the formation of neutrophil extracellular traps have recently been recognized as detrimental factors affecting tumorigenesis and progression. However, the role of abnormal ether lipid metabolism in colorectal cancer (CRC) evolution has not been repo...
2024-10-01 | MTBLS10323 | MetaboLights
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
MetabolomicsMetabolomics analyses of cancer tissue from patients with colorectal cancer.
The alteration of metabolism is essential for the initiation and progression of numerous types of cancer, including colorectal cancer (CRC). Metabolomics has been used to study CRC. At present, the reprogramming of the metabolism in CRC remains to be fully elucidated. In the present study, comprehen...
2024-02-08 | MTBLS8090 | MetaboLights
MetabolomicsCPT2 inhibition activates selective autophagy by enhancing glycerophospholipid biosynthesis in colorectal cancer

Metabolic reprogramming is one of the hallmark events in colorectal cancer (CRC).  Tumor cells adapt to microenvironmental changes by regulating energy and biomaterial metabolism. This study identified abnormal lipid accumulation and significant downregulation of fatty acid metabolism in CRC...

2025-09-01 | MTBLS12783 | MetaboLights
MetabolomicsVisceral obesity-Induced METTL27 regulation of the FABP5/PPARD/CPT1A axis in promoting colorectal cancer progression

The incidence of obesity and colorectal cancer (CRC) is rising annually. Obesity, particularly visceral obesity, poses a serious health threat, yet the association of obesity with CRC progression, as well as the role of visceral obesity, remains debated. This study analyzed 394 CRC patients ...

2025-10-06 | MTBLS13095 | MetaboLights
MetabolomicsA KRAS-triggered lactylation cascade forms the basis of chemotherapy resistance in colorectal cancer

KRAS-mutant colorectal cancer (KRASmut CRC) exhibits metabolic plasticity and chemoresistance, but the underlying mechanisms remain incompletely understood. Here, we show in CRC cells and organoids that KRAS-driven lactate accumulation promotes MCT1 K224 lactylation, which stabilizes mitochondria...

2026-10-16 | MTBLS16031 | MetaboLights
MetabolomicsSpatial and Untargeted Metabolomics Define Location- and Histology-Specific Metabolic Reprogramming in Colorectal Cancer

Colorectal cancer (CRC) exhibits profound molecular heterogeneity based on primary tumor location. A comprehensive understanding of the spatially resolved metabolic differences between right-sided (RCC) and left-sided (LCC) carcinomas remains elusive. Here, to eliminate the influence of inter-ind...

2026-03-24 | MTBLS13729 | MetaboLights
MetabolomicsDecoding the Human Gut Bacterial Plasmids in Colorectal Cancer
Gut plasmids show heightened sensitivity to gut microenvironmental changes compared to their bacterial hosts. To explore their significance in colorectal cancer (CRC), we analyzed metagenomic data from 863 participants (312 CRC, 387 high-risk, 164 low-risk). Plasmid and bacterial profiles were chara...
2026-04-26 | MTBLS14376 | MetaboLights
MetabolomicsA KRAS-triggered lactylation cascade forms the basis of chemotherapy resistance in colorectal cancer
KRAS-mutant colorectal cancer (KRASmut CRC) exhibits metabolic plasticity and chemoresistance, but the underlying mechanisms remain incompletely understood. Here, we show in CRC cells and organoids that KRAS-driven lactate accumulation promotes MCT1 K224 lactylation, which stabilizes mitochondrial M...
2026-10-16 | MTBLS16030 | MetaboLights
MetabolomicsDecoding the Human Gut Bacterial Plasmids in Colorectal Cancer
Gut plasmids show heightened sensitivity to gut microenvironmental changes compared to their bacterial hosts. To explore their significance in colorectal cancer (CRC), we analyzed metagenomic data from 863 participants (312 CRC, 387 high-risk, 164 low-risk). Plasmid and bacterial profiles were chara...
2026-04-24 | MTBLS14358 | MetaboLights
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