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MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
MetabolomicsCombined analysis of transcriptome and metabolome of large size triploid rainbow trout in different seasons
Seasonal temperature variation poses a major physiological challenge for cold-water aquaculture species, yet the molecular mechanisms underlying seasonal adaptation in large-sized triploid rainbow trout (Oncorhynchus mykiss) remain largely unexplored. Here, we integrated liver transcriptomics and LC...
2026-07-11 | MTBLS15014 | MetaboLights
MetabolomicsCombined NMR and MS Analysis of PC patient serum (part-I)
Not available
ORGANISM(S): Homo sapiens 
ST001081 | MetabolomicsWorkbench
MetabolomicsCombined NMR and MS Analysis of PC patien serum (part-III)
Not available
ORGANISM(S): Homo sapiens 
ST001083 | MetabolomicsWorkbench
MetabolomicsCombined NMR and MS Analysis of PC patien serum (part-II)
Not available
ORGANISM(S): Homo sapiens 
ST001082 | MetabolomicsWorkbench
MetabolomicsRapid chromatography combined with trapped ion mobility mass spectrometry for analysis of derivatized small molecules
Liquid chromatography (LC) separates biomolecules based on their physicochemical properties. Reproducible retention times support compound identification, while efficient separation of structurally similar compounds is essential for accurate quantification. However, conventional LC methods are often...
2026-06-30 | MTBLS14813 | MetaboLights
MetabolomicsIntegrated transcriptome-metabolome analysis reveals attenuated combined toxicity: Antagonistic interactions of three thermal processing contaminants in murine kidney-urine systems

To investigate the toxicological effects after individual or combined sub-chronical exposure to oxidized triacylglycerols, aldehydes, and 3-MCPDE formed during thermal processing of high-fat foods, this study implemented transcriptome-metabolome analysis of renal tissues in Kunming mice, suppleme...

2026-02-25 | MTBLS13934 | MetaboLights
MetabolomicsCombined analysis of cecal microbiota and metabolomics reveals the intervention mechanism of Dayuan Yin in acute lung injury

The ancient Chinese medicinal formula, Dayuan Yin (DYY), has a long history of use in treating respiratory ailments and shown to be effective in treating acute infectious diseases. This study aims to explore how DYY may impact intestinal flora and metabolites induced by acute lung injury (ALI). A...

2024-09-20 | MTBLS10741 | MetaboLights
MetabolomicsCombined analysis of transcriptome and metabolome reveals the accumulation of related metabolites and gene regulation networks during faba bean seed development

Background: Faba bean seeds are nutrient-dense, serving as a vital plant-based protein source for food and vegetables. However, the metabolic accumulation and transcriptional regulatory networks during seed development remain poorly understood.

Results: Metabolomic analysis of two developme...

2025-09-02 | MTBLS12471 | MetaboLights
MetabolomicsMetabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway
Metabolic perturbations resulting from excessive hepatic fat accumulation are poorly understood. Thus, in this study, leptin-deficient ob/ob mice, a mouse model of fatty liver disease, were used to investigate metabolic alterations in more detail. Metabolites were quantified in intact liver tissues ...
2018-01-31 | MTBLS400 | MetaboLights
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