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ModelsConradie2010_RPControl_CellCycle
This model is from the article: Restriction point control of the mammalian cell cycle via the cyclin E/Cdk2:p27 complex. Conradie R, Bruggeman FJ, Ciliberto A, Csikász-Nagy A, Novák B, Westerhoff HV, Snoep JL FEBS J.2010 Jan; 277(2): 357-67 20015233, ...
2024-09-02 | BIOMD0000000265 | BioModels
TranscriptomicsThe transcription factor nurr1 exerts concentration-dependent effects on target genes mediating distinct biological processes
The transcription factor nurr1 plays a pivotal role in the development and maintenance of neurotransmitter phenotype in midbrain dopamine neurons. Conversely, decreased nurr1 expression is associated with a number of dopamine-related CNS disorders, including Parkinson’s disease and drug addiction. I...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-33434 | biostudies-arrayexpress
MetabolomicsMetabolome analysis via an HPLC-ESI-MS-based experimental and computational pipeline for chronic nephron toxicity profiling
Untargeted metabolomics has the potential to improve the predictivity of in vitro toxicity models and therefore may aid the reduction of expensive and laborious animal models. Here we describe a chronic nephrotoxicity study conducted on a human renal proximal tubular epithelial cell line (RPTEC/TERT...
2015-09-07 | MTBLS140 | MetaboLights
TranscriptomicsFlusilazole dose response in zebrafish embryo
The zebrafish embryotoxicity test (ZET) is considered as a useful alternative model in predictive toxicology. Currently, morphological assessment of the embryo is the main readout for this assay. However, implementation of transcriptomics may help to detect more subtle effects which may increase the...
ORGANISM(S): Danio rerio 
2012-03-21 | E-MTAB-832 | biostudies-arrayexpress
MetabolomicsDried blood spots analysis for targeted and non-targeted exposomics

Dried blood spots (DBS) are an established sample type, widely used in newborn screening programs for monitoring metabolic diseases. Their minimally invasive nature offers great promise for assessing chemical exposures, particularly during early life stages and in large-scale epidemiological stud...

2025-10-09 | MTBLS13065 | MetaboLights
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
ProteomicsDiscovery of the targets of the immune response to chronic lymphocytic leukemia in 2 patients using protein microarrays
The binding of serum immunoglobulins to proteins was compared using serum from after and before an immunotherapeutic intervention (donor lymphocyte infusion) in two patients who had relapsed chronic lymphocytic leukemia (CLL) after bone marrow transplant. One Invitrogen ProtoArray was used for each ...
ORGANISM(S): Homo sapiens 
2008-05-31 | E-GEOD-11564 | biostudies-arrayexpress
TranscriptomicsConcentration dependent gene expression changes in Daphnia magna exposed to metals
To determine dose-dependent effects of metal exposure we performed microarray hybridizations with RNA isolated from Daphnia magna following Cu, Cd, and Zn exposures over a range of concentrations that included a tolerated concentration, a sublethal concentration, and a highly toxic concentration. Th...
ORGANISM(S): Daphnia magna 
2008-06-09 | GSE7668 | GEO
ProteomicsDiscovery of the targets of the immune response to chronic myeloid leukemia in 3 patients using protein microarrays
Three patients who had relapsed chronic myeloid leukemia after allogeneic bone marrow transplant and received an immunotherapeutic intervention (donor lymphocyte infusion, or DLI) without further treatment were studied. The binding of serum immunoglobulins to proteins after immunotherapy was compare...
ORGANISM(S): Homo sapiens 
2008-05-31 | E-GEOD-11565 | biostudies-arrayexpress
TranscriptomicsIdentification of host transcriptional networks showing concentration-dependent regulation by HPV16 E6 and E7 proteins in basal cervical squamous epithelial cells.
The W12 cell lineage recapitulates the early events in HPV-driven cervical cancer pathogenesis (which is impossible to investigate using clinical samples) and we are interested in characterising the host transcriptional events that occur at those early stages. Previous work in these cells has identi...
ORGANISM(S): Homo sapiens 
2016-11-30 | E-MTAB-4409 | biostudies-arrayexpress
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