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MetabolomicsZika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA

ZIKV infection is associated with testicular damage and abnormal spermatogenesis. However, the molecular mechanisms underlying these pathogenic processes remain unclear. Here, we demonstrate that ZIKV disrupts Leydig cells' ability to produce testosterone, leading to decreased sperm counts and mo...

2025-06-29 | MTBLS12549 | MetaboLights
TranscriptomicsUsing next generation sequencing to study the genetic diversity of candidate live attenuated Zika vaccines
Zika virus (ZIKV) is a mosquito-transmitted positive-sense RNA virus in the family Flaviviridae. Candidate live-attenuated vaccine (LAV) viruses with engineered deletions in the 3’UTR provide immunity and protection in animal models of ZIKV infection, and phenotypic studies show that LAVs retain pro...
ORGANISM(S): Zika virus 
2020-04-13 | E-MTAB-8905 | biostudies-arrayexpress
ProteomicsCharactering the lipidome of Huh7 Zika infected cells at 24hpi and 48hpi
Lipidomic analysis of Huh7 cells infected with Zika FSS13025 at an MOI of ~10. Samples collected at 24 and 48 hrs post infection.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-10-29 | MSV000083079 | MassIVE
GenomicsGENETIC EVALUATION IN CONGENITAL ZIKA SYNDROME
GENETIC EVALUATION IN CHILDREN WITH EYE ANOMALIES ASSOCIATED WITH CONGENITAL ZIKA SYNDROME
PRJEB40869 | ENA
TranscriptomicsBinding of the Zika virus genome to endogenous human transcripts
This study aims to study binding events between the Zika virus RNA genome and endogenous transcripts during infection of a human cell line. We develop a novel psolaren-based cross-linking technique to preserve interactions between mRNA and the Zika genome. Interacting RNA molecules are ligated toget...
ORGANISM(S): Homo sapiens 
2018-07-13 | E-MTAB-6427 | biostudies-arrayexpress
ProteomicsMulti-omics approach reveals serum biomarker candidates for Congenital Zika Syndrome
During pregnancy, the Zika virus (ZIKV) can be vertically transmitted, causing Congenital Zika Syndrome (CZS) in fetuses. ZIKV infection in early gestational trimesters increases the chances to develop CZS. This syndrome involves several pathologies with a difficult diagnosis, which usually occurs i...
ORGANISM(S): Homo sapiens (Human) 
2024-07-02 | PXD043324 | Pride
Zika virus  proteomics  metabolomics  multi-omics  congenital zika syndrome  microcephaly  serum  biomarkers 
ProteomicsSerum proteomics of infants in utero exposed to Zika virus without Congenital Zika Syndrome
In 2015, ZIKV infection attracted international attention during an epidemic in the Americas, when neurological disorders were reported in babies who had their mothers exposed to ZIKV during pregnancy. World Health Organization (WHO) epidemiological data show that 5 to 15% of neonates exposed to ZIK...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020294 | Pride
Zika virus Czs Serum 
ProteomicsGlycerophospholipid and amino acid metabolism impairment during Congenital Zika Syndrome development
Zika virus (ZIKV) can be transmitted vertically to the fetus, having a high chance to develop Congenital Zika Syndrome (CZS). Studies have shown that ZIKV impairs brain development. However, little is known about the molecular differences between non- microcephalic ZIKV-infected fetuses and microcep...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD039643 | Pride
Metabolomics Congenital zika syndrome Amino acid metabolism Zika virus Glycerophospholipid metabolism Amniotic fluid 
TranscriptomicsInter and intra-lineage genetic diversity of Zika virus differs for American isolates
Zika virus (ZIKV) is a mosquito-transmitted positive-sense RNA virus in the family Flaviviridae. ZIKV infections are associated with neurodevelopmental deficiencies termed Congenital Zika Syndrome. ZIKV strains are grouped into three phylogenetic lineages: East African, West African, and Asian, whi...
ORGANISM(S): Zika virus 
2018-12-31 | E-MTAB-5945 | biostudies-arrayexpress
TranscriptomicsInter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity
ZIKV strains belong to three phylogenetic lineages: East African, West African, and Asian/American. RNA virus genomes exist as populations of genetically-related sequences whose heterogeneity may impact viral fitness, evolution, and virulence. The genetic diversity of representative ZIKVs (N=7) fro...
ORGANISM(S): Zika virus 
2019-07-30 | E-MTAB-7771 | biostudies-arrayexpress
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