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ProteomicsAMPK activation promotes transcriptional activation of TFEB through its dephosphorylation
Transcription Factor EB (TFEB) is a critical regulator of lysosomal biogenesis, autophagy and energy homeostasis through regulating expression of genes belonging to the Coordinated Lysosomal Expression and Regulation network. Recently, AMP-activated protein kinase (AMPK) was reported to phosphorylat...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-11 | PXD055410 | Pride
Bay-3827  coordinated lysosomal expression and regulation  mk-8722  reversible phosphorylation  mtor  tfe3 
GenomicsSTING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation
STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation
PRJNA1195557 | ENA
TranscriptomicsSTING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation
Lysosomes are essential organelles for cellular homeostasis. Defective lysosomes are associated with many human diseases, such as lysosomal storage disorders (LSD). How the cell detects lysosomal defects and then restores lysosomal function remain incompletely understood. Here, we show that STING me...
ORGANISM(S): Mus musculus Homo sapiens 
2025-04-23 | GSE283768 | GEO
GenomicsTFEB-vacuolar ATPase signaling regulates lysosomal activity and immune response in tauopathy
TFEB-vacuolar ATPase signaling regulates lysosomal activity and immune response in tauopathy
PRJNA905364 | ENA
UnknownMYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat.
Not available
S-EPMC6689058 | biostudies-literature
UnknownTFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy.
Not available
S-EPMC12203451 | biostudies-literature
UnknownTFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy.
Not available
S-EPMC9934527 | biostudies-literature
UnknownAxenic Culture of Caenorhabditis elegans Alters Lysosomal/Proteasomal Balance and Increases Neuropeptide Expression.
Not available
S-EPMC9570027 | biostudies-literature
UnknownImpaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis.
Not available
S-EPMC6844531 | biostudies-literature
UnknownVCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Not available
S-EPMC6526815 | biostudies-literature
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