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MetabolomicsApplication of the Protease-Resistant Antimicrobial Peptide R7I, Composed of Natural Amino Acids, as a Functional Food Ingredient for Modulating Intestinal Health

Foodborne pathogenic bacterial infections pose significant challenges to global food safety and public health, while the issue of antimicrobial resistance (AMR) has worsened in recent years, creating an urgent need for safe, natural alternatives to combat foodborne pathogens and associated intest...

2025-11-09 | MTBLS13292 | MetaboLights
TranscriptomicsKin28 Regulates the Transient Association of Mediator with Core Promoters
Mediator is an essential, broadly utilized eukaryotic transcriptional co-activator. How and what it communicates from activators to RNA polymerase II remains an open question. Here we performed genome-wide location profiling of yeast Mediator subunits. Mediator is not found at core promoters but rat...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-24 | E-GEOD-55402 | biostudies-arrayexpress
TranscriptomicsA lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation.
Expression data from CD34+ hematopoietic cells transduced with control or anti-SLPI shRNA, serum starved and treated with G-CSF. CD34+ hematopoietic cells were isolated from the bone marrow of healthy individuals, transduced with lenitvirus-based RFP-expressed shRNA constructs targeting SLPI mRNA or...
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-53353 | biostudies-arrayexpress
ProteomicsTime-resolved inducible knock-down of Clp protease subunits in tobacco identifies putative protease substrates
The Clp protease complex in plants is the one with the highest complexity through all life kingdoms. It is composed of 14 nuclear- and plastid-encoded subunits which are allocated in different rings across the complex. The proteolytic ring (P-ring; ClpP3-ClpP6) and non-proteolytic ring (R-ring; ClpR...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-22 | PXD008305 | Pride
Clp protease  chloroplast  protein degradation  protease substrate  nicotiana tabacum  inducible rnai  lc-msms  shotgun proteomics 
ProteomicsPRMT5: a Novel Regulator of Hepatitis B Virus Replication and an Arginine Methylase of HBV Core
In the study, we identified protein arginine methyltransferase 5 (PRMT5) as a novel restriction factor of HBV replication. We have also demonstrated that PRMT5 can interact with the HBV core and methylate its arginine residues within arginine-rich domain. We identified two types of HBc post-translat...
ORGANISM(S): Homo sapiens (Human) Hepatitis B virus 
2017-11-01 | PXD006828 | Pride
Ubiquitination Hepatitis b virus Arginine methylation Phosphorylation Hbv core protein 
UnknownHydrophobic core flexibility modulates enzyme activity in HIV-1 protease.
Not available
S-EPMC3391577 | biostudies-literature
TranscriptomicsGene expression profiling of genes differentially expressed by oral carcinoma Ca9-22 and SLPI-deficient Ca9-22 (ΔSLPI) cells
We used the myoma model in conjunction with gene expression profiling with microarray data as an efficient tool for high throughput analysis and to screen for differentially expressed genes. Our aim was to identify candidates playing an important role in SLPI and/or MMP-promoted tumor invasion by co...
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-78501 | biostudies-arrayexpress
GenomicsLack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice
Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice
PRJNA529677 | ENA
TranscriptomicsReaeration timecourse from a defined hypoxia model
Reaeration timecourse from a defined hypoxia model in Mycobacterium tuberculosis. The mechanism by which mycobacteria return to a replicating state upon re-exposure to favorable conditions is not well understood. In this study, we utilized reaeration from a defined hypoxia model to characterize the...
ORGANISM(S): Mycobacterium tuberculosis 
2010-07-28 | E-GEOD-21590 | biostudies-arrayexpress
UnknownA Chondroitin Sulfate Chain of Urinary Trypsin Inhibitor Enhances Protease Inhibitory Activity of the Core Protein.
Not available
S-EPMC8283410 | biostudies-literature
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