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MetabolomicsMetabolomics revealed the influence of breast cancer on lymphatic endothelial cell metabolism, metabolic crosstalk, and lymphangiogenic signaling in co-culture

Breast cancer metastasis occurs via blood and lymphatic vessels. Breast cancer cells 'educate' lymphatic endothelial cells (LECs) to support tumor vascularization and growth. However, despite known metabolic alterations in breast cancer, it remains unclear how lymphatic endothelial cell metabolis...

2024-06-25 | MTBLS859 | MetaboLights
MetabolomicsButyrate epigenetically licenses sustained epithelial-T cell crosstalk for intestinal immune tolerance

Butyrate, one of the most abundant microbial-derived metabolites in the gut, is important in regulating intestinal homeostasis. In this study, we used untargeted global metabolomics to landscape the intestinal epithelial cellular metabolites changed by butyrate treatment.

2026-06-26 | MTBLS14301 | MetaboLights
MetabolomicsThe Crosstalk between Microbiota and Metabolites in AP Mice Based on Metagenomics and Untargeted Metabolomics

BACKGROUND AND PURPOSE: The microbiota dysfunction aggravated the severity of acute pancreatitis (AP), but the relationship between microbiota dysfunction and metabolites alteration was not fully explained. This study aimed to explore the crosstalk between microbiota and metaboli...

2023-08-10 | MTBLS6831 | MetaboLights
MetabolomicsDecipher aging related skin microbiome and metabolites crosstalk from a chronologically matched cohort

Aging has shown close link to shifts in the skin microbiome in population cohort study. However, how variations in microbial communities relate to divergent skin aging within individuals of the same chronological ages remains unclear. In this study, we performed phenotypic, metabolomic and metage...

2025-01-03 | MTBLS11994 | MetaboLights
ProteomicsFAIMS enhances the detection of PTM crosstalk sites
Protein post-translational modification (PTMs) enable cells to rapidly change in response to biological stimuli. With over 400 PTMs, understanding these control mechanisms is complex. To date, efforts have focused on investigating the effect of single PTMs on protein function. Yet, many proteins con...
ORGANISM(S): Homo sapiens (Human) 
2025-03-11 | PXD026448 | Pride
Faims Lc-ms Post-translational modifications Interplay Crosstalk 
TranscriptomicsCrosstalk between two bZIP signaling pathways orchestrates salt-induced metabolic reprogramming in Arabidopsis roots
Soil salinity increasingly causes crop losses worldwide. Although roots are the primary targets of salt stress, the signaling networks that facilitate metabolic reprogramming to induce stress tolerance are less understood than those in leaves. Here, a combination of transcriptomic and metabolic appr...
ORGANISM(S): Arabidopsis thaliana 
2015-09-02 | E-GEOD-71001 | biostudies-arrayexpress
ProteomicsClinically Relevant Aβ42 Stereochemistry-Driven Proteome Perturbation, Aggregation Crosstalk and Cytotoxicity Inhibition: ABPP
The stereochemical modification of Aβ42 discovered in the clinical samples of Alzheimer's disease (AD) patients has attracted increasing attention. However, most existing studies have focused on the characteristic analysis of a single isomer, ignoring the complex interactions of the coexistence of m...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-20 | PXD065394 | Pride
Aβ42  alzheimer's disease  stereoisomeric modification  crosstalk effect  amyloid protein aggregation  neurotoxicity  abpp 
ProteomicsClinically Relevant Aβ42 Stereochemistry-Driven Proteome Perturbation, Aggregation Crosstalk and Cytotoxicity Inhibition: Cytotoxicity
The stereochemical modification of Aβ42 discovered in the clinical samples of Alzheimer's disease (AD) patients has attracted increasing attention. However, most existing studies have focused on the characteristic analysis of a single isomer, ignoring the complex interactions of the coexistence of m...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-20 | PXD065373 | Pride
Aβ42  alzheimer's disease  stereoisomeric modification  crosstalk effect  amyloid protein aggregation  neurotoxicity  abpp 
TranscriptomicsCrosstalk between Fgf and Wnt signaling in the zebrafish tailbud
We aimed to expand the knowledge of Fgf and Wnt signaling in the zebrafish tailbud. Both pathways are required for proper axis elongation and segmentation and we wished to explore the genes under the control of each pathway during this process. In addition, we saught to identify crosstalk between th...
ORGANISM(S): Danio rerio 
2012-07-15 | E-GEOD-38969 | biostudies-arrayexpress
ModelsLiu2010_Hormonal_Crosstalk_Arabidopsis
This is the single cell model for analysis of hormonal crosstalk in Arabidopsis described in the article: Modelling and experimental analysis of hormonal crosstalk in Arabidopsis. Liu J, Mehdi S, Topping J, Tarkowski P and Lindsey K. Mol Syst Biol. 20...
2024-09-02 | BIOMD0000000269 | BioModels
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