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TranscriptomicsSRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
The neuroendocrine (NE) phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the NE phenotype in CRPC. Expression of chromogranin A (CHGA), synaptophysin (SYP), androgen receptor (AR), and ...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-66187 | biostudies-arrayexpress
ProteomicsCRPC biomarker via proteomic analysis
Identifying biological change from hormone-naive prostate cancer to CRPC is a major clinical challenge for developing therapeutic agents. Although the pathways that lead to CRPC are not fully understood, recent evidence demonstrates that androgen signaling is often maintained through varied mechanis...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023592 | Pride
: comparative proteomics  prostate cancer  foxa1  androgen deprivation therapy  crpc 
TranscriptomicsMolecular Profiling of Metastatic Prostate Carcinoma Reveals Substantial Inter-individual and Limited Intra-individual Diversity: Implications for Precision Oncology
Prostate cancers exhibit a spectrum of molecular aberrations of which a substantial subset are amenable to targeted therapeutics. To determine the diversity of somatic alterations present in metastasis within and between individuals we characterized the genomic landscapes of 176 tumors acquired from...
ORGANISM(S): Homo sapiens 
2015-12-18 | E-GEOD-74685 | biostudies-arrayexpress
GenomicsHSPC and CRPC
Genetic alteration between HSPC and CRPC
PRJEB32473 | ENA
GenomicsPersistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions
The androgen receptor (AR) is a ligand-inducible transcription factor that mediates androgen action in target tissues. Upon ligand binding, the AR binds to thousands of genomic loci and activates a cell-type specific gene program. Prostate cancer growth and progression depend on androgen-induced AR ...
ORGANISM(S): Homo sapiens 
2012-10-02 | E-GEOD-40050 | biostudies-arrayexpress
GenomicsMeRIP sequencing for CSPC vs CRPC samples
MeRIP sequencing for CSPC vs CRPC samples
PRJNA916940 | ENA
GenomicsChimæra CRPC
Exome sequencing of 10 biopsies from the same CRPC tumor
PRJEB19193 | ENA
GenomicsLSD1 inhibition disrupts super-enhancer activities in CRPC [RNA-seq]
LSD1 inhibition disrupts super-enhancer activities in CRPC [RNA-seq]
PRJNA862884 | ENA
GenomicsLSD1 inhibition disrupts super-enhancer activities in CRPC [scRNA-seq]
LSD1 inhibition disrupts super-enhancer activities in CRPC [scRNA-seq]
PRJNA862883 | ENA
TranscriptomicsSubstantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer
Intraindividual tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that have metastasized. To determine whether the genomic alterations in a single metastasis provide a reasonable assessment of the major oncogenic drivers of other dispersed metastases in a...
ORGANISM(S): Homo sapiens 
2016-02-16 | E-GEOD-77930 | biostudies-arrayexpress
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