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The carboxy-terminal domain (CTD) of RNA polymerase II (Pol II) consists of heptad repeats with the consensus motif Y1-S2-P3-T4-S5-P6-S7. Dynamic phosphorylation of the CTD coordinates Pol II progression through the transcription cycle. Monoclonal antibodies have been used to study in vivo the poten...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2016-01-25 | PXD003159 | Pride
To investigate the role of RNA Pol II CTD acetylation we performed comprehensive deacetylase inhibition using common small-molecule inhibitors and performed ChIP-seq from mouse cells using antibodies against RNA Polymerase II CTD modifications: (8WG16, unmodified heptads; K7ac, acetylated heptads; 4...
ORGANISM(S): Mus musculus 
2019-01-12 | GSE124996 | GEO
Genome-wide analysis of RNA Pol II CTD modifications in resonse to lysine deacetylase inhibition
The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is composed of a repetition of YSPTSPS heptads and functions as a loading platform for protein complexes that regulate transcription, splicing and maturation of RNAs. Here, we studied mammalian CTD mutants to analyze the function of tyrosi...
ORGANISM(S): Homo sapiens 
2017-12-29 | GSE94330 | GEO
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